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Sheraz Gul (Fraunhofer-IME SP)

A high-throughput approach for measuring intracellular ATP levels to access compound-mediated cellular toxicity

30 November 2018 | By Maria Kuzikov (Fraunhofer-IME SP), Oliver Keminer (Fraunhofer Institute for Molecular Biology and Applied Ecology), Salma Hachim (Fraunhofer Institute for Molecular Biology and Applied Ecology), Sheraz Gul (Fraunhofer-IME SP)

Many drugs fail in clinical trials due to toxicity-related issues; therefore, drug-mediated cellular toxicity should be determined at an early stage in the drug discovery value chain. There are many assay systems that can be utilised to measure cellular toxicity. In this article we demonstrate that intracellular ATP concentrations are…

The value of automating assays in screening

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The value of automating assays in screening

2 May 2018 | By Giulia Pasini, Sheraz Gul (Fraunhofer-IME SP)

This article compares and contrasts a commonly used cell viability assay in manual and automated fashion and provides exemplar data from each scenario.

Phenotypic and target-based screening: complementary or competing?

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Phenotypic and target-based screening: complementary or competing?

11 July 2017 | By Sheraz Gul (Fraunhofer-IME SP)

The screening of drug targets against compound libraries is now a mature and validated approach to identifying the chemical starting points of drugs...

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Using clinical drug resistance to kill cancer cells

11 July 2017 | By Howard Fearnhead - NUI Galway, Sheraz Gul (Fraunhofer-IME SP)

Drug resistance is a significant therapeutic problem, from infectious diseases to cancer. Given a large enough population of genetically varying target cells, the emergence of drug resistance is not surprising and is even unavoidable...

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Application note: The reliability of assay-ready plates for cell-based screening enabled by the Echo® 550 Liquid handler

9 June 2017 | By Enda O’Connell (National University of Ireland Galway), Howard Fearnhead (National University of Ireland Galway), Markus Wolf (Fraunhofer-IME SP), Sheraz Gul (Fraunhofer-IME SP)

In this application note, Sheraz Gul (Fraunhofer-IME SP), Markus Wolf (Fraunhofer-IME SP), Enda O’Connell (National University of Ireland Galway) and Howard Fearnhead (National University of Ireland Galway), demonstrate that the Echo 550 Liquid Handler can precisely and accurately transfer nanolitre volumes of compound with acoustic energy in a completely contact-free…

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Stem Cells In-Depth Focus 2016

16 June 2016 | By Andreas Reimer (CEO: Tangea), Anton Simeonov, David Bailey (IOTA Pharmaceuticals), Ilyas Singeç (National Center for Advancing Translational Sciences), Sheraz Gul (Fraunhofer-IME SP)

Featured in this Stem Cells In-depth Focus: Translating stem cell biology into drug discovery; Mechanism-informed phenotypic screening – the missing link for cancer drug discovery; Analysis of human stem cell interactions at the single-cell resolution...

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Mechanism-informed phenotypic screening – the missing link for cancer drug discovery?

8 June 2016 | By David S. Bailey (IOTA Pharmaceuticals), Sheraz Gul (Fraunhofer-IME SP)

Cancer cells exhibit huge phenotypic diversity, with many well-defined phenotypes, such as invasion, deregulated proliferation and immune evasion, contributing to disease outcomes, making them uniquely amenable to phenotypic screening1...

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An overview of Alzheimer’s disease drug targets

17 February 2016 | By Maria Kuzikov (Fraunhofer-IME SP), Sheraz Gul (Fraunhofer-IME SP)

Alzheimer’s disease (AD) is the most common form of dementia which typically occurs after the age of 65 and is characterised by progressive cognitive impairment...

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The importance of adequately triaging hits from HTS campaigns

19 June 2015 | By Kamyar Hadian (Institute of Molecular Toxicology and Pharmacology), Kenji Schorpp (Institute of Molecular Toxicology and Pharmacology), Sheraz Gul (Fraunhofer-IME SP)

High throughput screening (HTS) continues to be employed in drug discovery as the primary source of identifying chemical starting points for drug discovery and tool compounds for chemical biology, respectively. Although small molecule drug discovery efforts have focused largely upon enzyme, receptor and ion-channel targets, there has been an increase…

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The quest for accurate target validation

9 April 2015 | By Sheraz Gul (Fraunhofer-IME SP)

Preview of the upcoming foreword in our April issue, written by Sheraz Gul, Vice President and Head of Biology at Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Hamburg, Germany...

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Workshop Review: Cell-based Assays for Screening (December 2014)

9 April 2015 | By Sheraz Gul (Fraunhofer-IME SP)

Sheraz Gul, Head of Biology at Fraunhofer-IME SP, provides an in-depth review of the Cell-Based Assays for Screening workshop which took place in December 2014...

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Collaborative drug discovery: an update on the progress of such initiatives

29 October 2013 | By Sheraz Gul (Fraunhofer-IME SP)

Despite the ever increasing efforts being expended for drug discovery purposes, the number of approved drugs remains relatively static. A variety of explanations have been provided to explain this observation and initiatives to remedy this situation have been implemented. Many of these initiatives are still works-in-progress and whether these will…

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Sheraz Gul (Fraunhofer-IME SP)