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Inhibiting REST gene could be clue to new diabetes treatments
A study has shown that inhibiting the REST gene boosted insulin-producing cells during early pancreas development in animals.
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Novel insulin-producing implant to be created for type 1 diabetics
JDRF funds development of an insulin-producing implant to regulate blood glucose levels in type 1 diabetes patients.
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Small molecule to potentially treat diabetes discovered in screening study
A small molecule found in a cell-based ultra-high-throughput screening campaign was shown to treat diabetes in cells and mice.
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Tiny implant cures diabetes in mice without triggering immune response
Scientists have developed an implant that releases insulin-secreting cells which has shown success at treating diabetes in mice.
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Genomic analysis reveals cellular cause of type 1 diabetes
Combining two genomic methodologies, researchers have shown that pancreatic exocrine cells are implicated in type 1 diabetes.
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Exploring the connection between COVID-19 and diabetes
Dr Brittany Busse discusses why COVID-19 can influence the onset of diabetes and how this could shape the development of therapeutics.
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Experimental mAb subdues type 1 diabetes in laboratory mice
A monoclonal antibody given to mice reversed type 1 diabetes by suppressing the actions of glucagon, a study has shown.
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β-cell regeneration discovery could pave way for diabetes treatments
A key process in β-cell regeneration has been discovered by researchers who say this could lead to improved treatments for diabetes.
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A single approach to creating effective cancer and autoimmune disease therapeutics
Dr H. Michael Shepard, CEO and CSO of Enosi Life Sciences, discusses the similarities between cancer and autoimmune diseases, highlighting how this knowledge could be used to enhance treatments.
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Exploration of autoimmune disease target tissues reveals novel drug targets
Researchers suggest that identifying new treatments for autoimmune diseases requires studying the immune system AND target tissues together.
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Next-generation diabetes prodrugs identified using novel screening platform
Researchers engineered the Disque Platform, a high-fidelity culture system, to enable them to screen drugs able to promote β cell proliferation.
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New insulin molecule can self-regulate blood sugar in rats
Researchers have developed a novel insulin molecule that responds to glucose levels in the blood sugar of rats, which they say could help patients with type 1 diabetes.
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A novel CAR T-cell therapy for type 1 diabetes
Researchers show how genetically engineered five-module chimeric antigen receptor (5MCAR) T cells can be directed to destroy T cells causing autoimmune diseases.
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Oncology meets immunology – antibody-mediated regulation of the immune response
In this article, Aparajita Dubey discusses the role of antibodies in regulating the immune system and highlights key features that need to be considered for drug development and how this can be applied to cancer therapy.
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Researchers halt type 1 diabetes onset by denervating the pancreas
Scientists denervated the pancreas using surgery or pharmacological agents to protect it from immune-mediated beta cell destruction, preventing the onset of type 1 diabetes.
