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Psoriasis

Determining the structure of nanobodies using nuclear magnetic resonance spectroscopy

23 September 2021 | By Professor Gennaro Esposito (NYU Abu Dhabi)

Scientists at the New York University (NYU) Abu Dhabi have used nuclear magnetic resonance (NMR) techniques to determine the structure of a specific nanobody, Nb23. Drug Target Review’s Victoria Rees spoke with lead researcher Professor Gennaro Esposito to find out how their findings could lead to a better understanding of…

news

Targeting interferon kappa could control psoriasis inflammation

16 August 2021 | By Anna Begley (Drug Target Review)

Scientists found that changing interferon kappa levels altered the severity of psoriasis inflammation and cytokine production in mice.

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Self-assembling nanofibres could prevent damage from inflammation

15 April 2021 | By Victoria Rees (Drug Target Review)

A team has demonstrated in mouse models that a self-assembling nanofibre material could limit the damage caused by cytokines in inflammatory diseases.

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Treating cytokine storms in COVID-19 patients

23 October 2020 | By Dr Fiona McCann (CannBioRx Life Sciences), Dr H Michael Shepard (Enosi Life Sciences), Sir Marc Feldmann (Enosi Life Sciences)

Enosi Life Science researchers Sir Marc Feldmann, Dr H Michael Shepard and Dr Fiona McCann explain why anti-TNF therapies may be effective in treating COVID-19 associated cytokine storms and other inflammatory conditions.

RNA strands in orange on a blue background

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Novel siRNA therapy improves psoriasis in mice

19 October 2020 | By Hannah Balfour (Drug Target Review)

Topical delivery of a small interfering RNA (siRNA) using an ionic liquid complex significantly reduced levels of inflammatory cytokines and symptoms of psoriasis.

computer generated image of antibodies in blue, grey and green on a blue gradient background

article

Oncology meets immunology – antibody-mediated regulation of the immune response

10 September 2020 | By Aparajita Dubey (CRAMbridge)

In this article, Aparajita Dubey discusses the role of antibodies in regulating the immune system and highlights key features that need to be considered for drug development and how this can be applied to cancer therapy.

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Inhibiting VEGFA signalling protects mice against psoriasis

13 January 2020 | By Hannah Balfour (Drug Target Review)

Researchers have found inhibiting vascular endothelial growth factor A (VEGFA) signalling can mediate psoriasis development in the epidermis and could be a potential target for novel therapies.

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Inflammatory regulatory protein identified by researchers

22 November 2019 | By Victoria Rees (Drug Target Review)

A study has discovered that the PKM2 protein plays a role in regulating immune cells and blocking this could be a potential treatment for inflammatory diseases.

news

New imaging tools that trace key breast cancer enzymes may help guide therapies

7 December 2018 | By Drug Target Review

Series of molecules may provide more reliable relief with fewer side effects...

news

Psoriasis treated with compound derived from immune cells

19 April 2018 | By Dr Zara Kassam (Drug Target Review)

A compound may be effective against other autoimmune diseases, mouse study shows...

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Venomous compounds may lead to better skin treatments

11 September 2017 | By Dr Zara Kassam (Drug Target Review)

Compounds derived from fire ant venom can reduce skin thickening and inflammation in psoriasis...

news

Largest psoriasis meta-analysis to date yields new genetic clues

24 May 2017 | By Niamh Marriott (Drug Target Review)

1-2% of the US population have psoriasis, an immune-mediated disease that causes red, patchy and scaly marks on the skin.

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Anti-inflammatory drugs could treat symptoms of depression

18 October 2016 | By Niamh Louise Marriott, Digital Content Producer

Anti-inflammatory drugs, like those used to treat rheumatoid arthritis and psoriasis could in future be used to treat some cases of depression...

news

Researchers identify a key molecule in psoriasis development

4 October 2016 | By Niamh Louise Marriott, Digital Content Producer

To go further in the TREX2 role in homeostasis and skin pathogenesis, the researchers wanted to see the role of this nuclease on psoriasis...

news

Possible new target for psoriasis identified

13 June 2016 | By Victoria White, Digital Content Producer

A small protein in the skin called Rac1 appears to link well-known environmental triggers of the disease with a genetic predisposition to the condition...

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Psoriasis