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Cartilage growth gene TRPV4 shows promise for joint repair therapy
The discovery that the TRPV4 gene regulates cartilage growth could lead to treatments for osteoarthritis and other cartilage diseases.
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Osteoarthritis
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Knee injection shows promise as osteoarthritis treatment in mice
Scientists have found that a new knee injection using nanomedicine could prevent the effects of osteoarthritis.
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Combination therapy of α -KLOTHO and TGFβR2 improves osteoarthritis
A study has shown that a combination of α-KLOTHO and TGF β receptor 2 (TGFβR2) recovers cartilage in rats with osteoarthritis and could be a new therapy for humans.
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CRISPR: kick-starting the revolution in drug discovery
Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…
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Why do we have no effective treatments for osteoarthritis?
Osteoarthritis (OA) is a painful and debilitating disease of articular joints.1,2 Its clinical prevalence is as high as 21.6 percent of the population in the United States,3 which constitutes direct health costs of over 80 billion US dollars annually.4
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Assays In-Depth Focus 2019
In this In-Depth Focus: the importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays, and why do we have no effective treatments for osteoarthritis?
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Genetic study reveals possible new routes to treating osteoarthritis
Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines...
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Nine osteoarthritis genes discovered, paving way for new therapies
In the largest study of its kind, nine novel genes for osteoarthritis have been discovered...
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Nanopore sensors used to detect molecular biomarkers for osteoarthritis
Scientists have been able to measure a specific molecule indicative of osteoarthritis and a number of other inflammatory diseases using a newly developed technology...
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Small molecule could make a big difference for arthritis patients
Scientists have discovered a molecule that enhances cartilage regeneration and decreases inflammation.
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Researchers find new genes link to arthritis in bone marrow lesions
Researchers have found a pattern of genes which is characteristic of osteoarthritis and may be a step towards better treatments for this condition.
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Researchers print stem cells using 3D bioprinter to form cartilage
A team of researchers have generated cartilage tissue by printing stem cells using a 3D-bioprinter...
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Removing old cells could extend joint health & stop osteoarthritis
In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.
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Regenerating bone and cartilage tissues from apple waste
Researchers from UPM and CSIC have employed waste from the agri-food industry to develop biomaterials that are able to act as matrices to regenerate bone and cartilage tissues, which is of great interest for the treatment of diseases related to ageing.
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GlobalData says Osteoarthritis market to reach $10.5 billion by 2024
20 September 2016 | By Niamh Louise Marriott, Digital Content Producer
The rapid growth of the Osteoarthritis can be attributed to the launch of new therapies priced at a substantial premium to small-molecule therapies...
