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Osteoarthritis

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Cartilage growth gene TRPV4 shows promise for joint repair therapy

26 August 2021 | By Anna Begley (Drug Target Review)

The discovery that the TRPV4 gene regulates cartilage growth could lead to treatments for osteoarthritis and other cartilage diseases.

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Knee injection shows promise as osteoarthritis treatment in mice

18 January 2021 | By Victoria Rees (Drug Target Review)

Scientists have found that a new knee injection using nanomedicine could prevent the effects of osteoarthritis.

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Combination therapy of α -KLOTHO and TGFβR2 improves osteoarthritis

22 January 2020 | By Hannah Balfour (Drug Target Review)

A study has shown that a combination of α-KLOTHO and TGF β receptor 2 (TGFβR2) recovers cartilage in rats with osteoarthritis and could be a new therapy for humans.

article

CRISPR: kick-starting the revolution in drug discovery

13 December 2019 | By Dr Pushpanathan Muthuirulan (Harvard University)

Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…

article

Why do we have no effective treatments for osteoarthritis?

20 April 2019 | By Pradeep Sacitharan

Osteoarthritis (OA) is a painful and debilitating disease of articular joints.1,2 Its clinical prevalence is as high as 21.6 percent of the population in the United States,3 which constitutes direct health costs of over 80 billion US dollars annually.4

article

Assays In-Depth Focus 2019

14 March 2019 | By Drug Target Review

In this In-Depth Focus: the importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays, and why do we have no effective treatments for osteoarthritis?

news

Genetic study reveals possible new routes to treating osteoarthritis

23 January 2019 | By Dr Zara Kassam (Drug Target Review)

Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines...

news

Nine osteoarthritis genes discovered, paving way for new therapies

20 March 2018 | By Dr Zara Kassam (Drug Target Review)

In the largest study of its kind, nine novel genes for osteoarthritis have been discovered...

news

Nanopore sensors used to detect molecular biomarkers for osteoarthritis

13 March 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have been able to measure a specific molecule indicative of osteoarthritis and a number of other inflammatory diseases using a newly developed technology...

news

Small molecule could make a big difference for arthritis patients

13 February 2018 | By Drug Target Review

Scientists have discovered a molecule that enhances cartilage regeneration and decreases inflammation.

news

Researchers find new genes link to arthritis in bone marrow lesions

19 July 2017 | By Niamh Marriott (Drug Target Review)

Researchers have found a pattern of genes which is characteristic of osteoarthritis and may be a step towards better treatments for this condition.

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Researchers print stem cells using 3D bioprinter to form cartilage

2 May 2017 | By Niamh Marriott (Drug Target Review)

A team of researchers have generated cartilage tissue by printing stem cells using a 3D-bioprinter...

news

Removing old cells could extend joint health & stop osteoarthritis

27 April 2017 | By Niamh Marriott (Drug Target Review)

In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.

news

Regenerating bone and cartilage tissues from apple waste

3 April 2017 | By Niamh Marriott (Drug Target Review)

Researchers from UPM and CSIC have employed waste from the agri-food industry to develop biomaterials that are able to act as matrices to regenerate bone and cartilage tissues, which is of great interest for the treatment of diseases related to ageing.

news

GlobalData says Osteoarthritis market to reach $10.5 billion by 2024

20 September 2016 | By Niamh Louise Marriott, Digital Content Producer

The rapid growth of the Osteoarthritis can be attributed to the launch of new therapies priced at a substantial premium to small-molecule therapies...

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Osteoarthritis