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Biomarkers identified that predict immunotherapy success
Researchers in Switzerland have identified biomarkers in the blood that can predict which patients are likely to respond favourably to immunotherapy treatment for cancer.
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Lung cancer
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Lung tumours communicate with bones to progress disease
Scientists at Massachusetts General Hospital (MGH) have identified how a type of lung cancer co-opts a portion of the immune system via bone marrow to increase tumour progression.
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N-alpha-acetyltransferase D found to promote lung cancer progression
NatD, which mediates N-alpha-terminal acetylation of histone H4, found to promote lung cancer progression...
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Genetic testing leads to response in MET fusion lung cancer
Researchers have identified a rare fusion involving the gene MET leading researchers to treat the cancer with a targeted therapy...
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New imaging technique may predict the of spread breast cancer
Researchers have developed a radioactive ‘tracer’ molecule to detect myeloid-derived suppressor cells’ accumulating in the lung in preparation for the arrival of breast cancer cells...
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Novel immuno-oncology treatment for patients with advanced solid tumours
An experimental immuno-oncology treatment will move into early phase clinical trials for patients with advanced solid tumours...
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Power of radiomics to improve precision medicine
Data mining of medical images with radiomics offers clinicians a way to characterise lung tumours and improve precision medicine...
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Largest genome-wide study of lung cancer susceptibility conducted
A new study conducted by an international team of lung cancer researchers have identified new genetic variants for lung cancer risk.
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Lung cancer screening could save money as well as lives, research shows
Lung cancer screening is likely to be cost-effective, particularly if it also identifies other tobacco-related conditions in high-risk people, suggests new research.
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Tracking unstable chromosomes helps predict lung cancer’s return
Scientists have found that unstable chromosomes within lung tumours increases the risk of cancer returning after surgery, and have used this new knowledge to detect relapse long before standard testing.
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£2.5 million Cancer Research UK collaboration to target ‘undruggable’ RAS
Scientists will develop and test promising new molecules for targeting RAS, one of the most common driving mutations in aggressive, hard to treat cancers including pancreatic and lung cancer.
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Stem cell ‘marking’ study offers alternative hypothesis of cancer metastasis
Stem cells are among the most energetically activated, migratory and proliferative sub-populations of tumour cells, according to observations by scholars at the Biomedical Research Centre at the University of Salford.
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AbbVie and Bristol-Myers Squibb announce lung cancer clinical trials collaboration
25 July 2016 | By Niamh Louise Marriott, Digital Content Producer
AbbVie and Bristol-Myers Squibb Company today announced a clinical trial collaboration to evaluate the safety, tolerability and efficacy of AbbVie’s investigational biomarker-specific antibody drug conjugate Rova-T...
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Advancing FLIP inhibitors for the treatment of NSCLC
26 April 2016 | By Victoria White, Drug Target Review
In an exclusive interview, Trevor Perrior, Research Director at Domainex, discusses the cell death regulatory protein FLIP and the potential of FLIP inhibitors as a treatment for NSCLC...
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Queen’s University Belfast and Domainex secure award to advance FLIP inhibitor
26 April 2016 | By Victoria White, Digital Content Producer
Queen’s University Belfast and Domainex have secured an award to advance therapeutic candidate molecules into clinical evaluation for treatment of NSCLC...
