news Mutated PCSK9 gene protects against liver damage and cardiovascular disease, say researchers 20 November 2020 | By Hannah Balfour (Drug Target Review) Scientists suggest the PCSK9Q152H gene variant may act as a “fountain of youth”, allowing people to live longer, healthier lives.
news CRISPR ‘minigene’ used to prevent genetic liver disease in mice 13 February 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a new CRISPR technique, using a minigene, which was inserted into mouse DNA, resulting in improved liver disease symptoms.
news Phage therapy shows potential to treat alcoholic liver disease 14 November 2019 | By Rachael Harper (Drug Target Review) Researchers have discovered that patients with alcoholic hepatitis had high numbers of a destructive gut bacterium and they were able to use a cocktail of phages to target and kill the bacteria, eradicating the disease.
news 3D liver tissue made from stem cells show promising support of liver function 5 September 2018 | By Drug Target Review Stem cells transformed into 3D human liver tissue by scientists show promising support of liver function when implanted into mice with a liver disease...
news E06 antibody blocks inflammation from hardened arteries and liver disease 8 June 2018 | By Dr Zara Kassam (Drug Target Review) Study uncovers new potential therapeutic approach for a number of diseases linked to inflammation, including atherosclerosis, aortic stenosis and hepatic steatosis...
news Alpha-1 antitrypsin deficiency shows promise in rare liver disease 20 October 2017 | By Dr Zara Kassam (Drug Target Review) Nuclease-free gene editing has been found to correct mutated cells ...
news New drug targets for a rare kidney and liver disease 24 August 2017 | By Dr Zara Kassam (Drug Target Review) In a joint international study, researchers have collaborated to uncover how mutations in a single gene called PKHD1 lead to symptoms associated with a rare kidney and liver disease...
news Scientists discover immune system blind spot in hepatic cirrhosis 20 July 2016 | By Victoria White, Digital Content Producer The discovery could lead to new treatments for bacterial infections, a leading cause of death in hepatic cirrhosis, without the need for antibiotics...
article Strategies for identifying predictive biomarkers of non-alcoholic fatty liver disease 17 March 2016 | By James Adjaye (Heinrich-Heine-University), Marie-Ann Kawala (Heinrich-Heine-University), Nina Graffmann (Heinrich-Heine-University), Wasco Wruck (Heinrich-Heine-University) Non-alcoholic fatty liver disease (NAFLD), a consequence of sedentary life styles and high fat diets, has an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within genes such as PNPLA3, TM6SF2, APOC3, NCAN and PPP1R3B correlate…
news Forbion invests in Akarna Therapeutics’ $15 Million Series B Financing 16 February 2016 | By Victoria White Akarna has said it will use the funds to accelerate the development of its lead FXR agonist drug candidate...
news JQ1 prevents and reverses liver fibrosis in mice 9 December 2015 | By Victoria White The discovery, made by scientists from the Salk Institute, could help the millions of people worldwide affected by liver fibrosis and cirrhosis, caused by alcoholism and diseases like hepatitis...
news Functional human hepatocytes grown in the lab 30 November 2015 | By Victoria White This groundbreaking development could help advance a variety of liver-related research and applications...
news Breakthrough in fighting liver disease 3 September 2015 | By Victoria White The University of Brighton has announced it is sharing in a €5.9m EU grant to support the development of a new treatment for chronic liver disease...
news MRC scientists regrow liver from liver stem cells 21 July 2015 | By Victoria White Medical Research Council (MRC) scientists have repaired a damaged liver in a mouse by transplanting liver stem cells grown in the laboratory...
news Protein from Vibrio vulnificus can inhibit tumour cell growth by cutting the protein Ras 9 June 2015 | By Victoria White Scientists have discovered that a toxin secreted by Vibrio vulnificus has potential to prevent the growth of tumours by cutting the protein Ras...
