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Liver cancer

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Study of liver cancer reveals MAGEA3 gene as new drug target

25 June 2021 | By Victoria Rees (Drug Target Review)

A study has shown that blocking the gene expression of MAGEA3 in liver cancer cells prevents the tumour from proliferating.

news

Newly identified protein could become target for cancer immunotherapy

7 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have found a protein that, when inhibited in mice with cancer, increased the response to immunotherapy.

news

Small molecule screens reveal new class of anticancer compounds

12 May 2021 | By Victoria Rees (Drug Target Review)

Two screening techniques were used by researchers to find anticancer compounds that target the aryl hydrocarbon receptor.

article

Could metabo-oncology be the treatment modality of the future?

8 February 2021 | By Victoria Rees (Drug Target Review)

Jim Shanahan from SynDevRx explains why metabo-oncology treatment modalities could be the answer to a rise in metabolic disorders and cancers.

news

Cancer-killing virus could improve precision medicine

2 December 2020 | By Victoria Rees (Drug Target Review)

A new cancer-killing virus called CF33 has shown success in pre-clinical trials, helping the immune system to eradicate tumours.

article

Current state of NAFLD treatments and the promise of in vitro platforms towards better screening of drug candidates

4 June 2020 | By Aslihan Gokaltun (Harvard Medical School and Shriners Hospitals for Children), Beyza Bulutoglu (Harvard Medical School and Shriners Hospitals for Children), Camilo Rey-Bedón (Harvard Medical School and Shriners Hospitals for Children), Martin L Yarmush (Harvard Medical School and Shriners Hospitals for Children), Osman Berk Usta (Harvard Medical School and Shriners Hospitals for Children), Peony Banik (Harvard Medical School and Shriners Hospitals for Children)

The heterogeneous pathogenesis of metabolic fatty liver diseases presents researchers with numerous challenges when trying to develop a treatment. This article explores the spectrum of these diseases and presents a novel in vitro platform for screening drug candidates.

news

Normal liver cells may have the potential to kill cancer cells

26 November 2019 | By Rachael Harper (Drug Target Review)

A new discovery that healthy liver tissue surrounding a tumour activates a defence mechanism that restrains tumour growth could inspire new therapeutic approaches that mobilise normal cells to kill cancer cells.

news

Function of protein involved in liver cancer discovered

30 October 2019 | By Rachael Harper (Drug Target Review)

The involvement of clathrin in the development of liver cancer has been described for the first time, which could lead to more targeted therapy.

news

New potential liver cancer treatment found with biomarker-guided strategy

16 July 2019 | By European Pharmaceutical Review

A cellular pathway may reduce side effects and extend immunotherapy duration in patients with the most common form of liver cancer.

news

Biomarkers to detect and prevent liver cancer

31 October 2018 | By Iqra Farooq (Drug Target Review)

An increase in the expression of sugar-burning 'glycolytic' enzymes in precancerous cirrhotic livers has been identified and could be used as a biomarker...

news

Amazonian plant provides anti-tumour activity

1 October 2018 | By Iqra Farooq (Drug Target Review)

A plant from the Amazonian region of Colombia has shown anti-tumour properties against human liver cancer cells, but not against healthy cells...

news

3D liver tissue made from stem cells show promising support of liver function

5 September 2018 | By Drug Target Review

Stem cells transformed into 3D human liver tissue by scientists show promising support of liver function when implanted into mice with a liver disease...

news

Potential peptide drug could treat liver cancer effectively

2 August 2018 | By Drug Target Review

Researchers have discovered that FFW and Sorafenib used together could reduce the growth of Sorafenib resistant hepatocellular carcinoma tumours...

news

pIC found to prevent the development of liver cancer

14 November 2017 | By Dr Zara Kassam (Drug Target Review)

A synthetic double-stranded RNA has potential for use as an anti-liver cancer vaccine...

news

Scrib protein identified as a natural suppressor of liver cancer

8 May 2017 | By Niamh Marriott (Drug Target Review)

A protein that typically helps keep cells organised and on task becomes a tumour suppressor in the face of liver cancer, scientists say.

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Liver cancer