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The study shows how drug-like small molecules inhibit the activity of Transient Receptor Potential Canonical 1/4/5 (TRPC1/4/5) channels and could transform the development of future therapies.
Research into alternative stem cell sources has identified urine derived renal progenitor cells (UdRPCs) as a possible option for use in regenerative kidney therapies in the future.
Kidneys are crucial for filtration of drugs and toxins and their proper function is essential for overall health. Unfortunately, due to disease and improper function, kidney transplantation or dialysis are necessary for millions of patients annually all over the world.1,2
A team of researchers set out to discover the disease pathways of a rare genetic kidney disease and found a compound that stops the disease in its tracks.
Results from a new study suggest that DNA sequencing could soon become part of the routine diagnostic examination for patients with chronic kidney disease.
The NIH has announced 13 two-year awards totalling $15m, to develop 3-D microphysiological system platforms that model human disease...
In a joint international study, researchers have collaborated to uncover how mutations in a single gene called PKHD1 lead to symptoms associated with a rare kidney and liver disease...
28 June 2016 | By Victoria White, Digital Content Producer
Researchers have used virtual tissue technology to identify a potential new drug target in the fight against polycystic kidney disease...
3 June 2016 | By Victoria White, Digital Content Producer
Researchers are to examine DNA samples from 20,000 people with diabetes to help identify the genetic factors in diabetic kidney disease...
7 March 2016 | By Victoria White
A team, led by Professor Elena Levtchenko from KU Leuven, discovered that kidney stem cells are abundant in the urine of premature babies...
18 December 2015 | By Victoria White
Variant says VAR 200 has potential for treating multiple indications associated with the damaging effects of cellular accumulation of cholesterol and lipids on the kidney, including focal segmental glomerulosclerosis...
23 October 2015 | By Victoria White
The work paves the way for personalised drug discovery for kidney disease...
8 October 2015 | By Victoria White
The breakthrough could allow the use of mini-organs to screen drugs either for the treatment of kidney disease or to find out if a new drug is likely to injure the kidney...
17 June 2015 | By Victoria White
AstraZeneca is to collaborate with Inserm to investigate new therapeutic approaches to type 2 diabetes and Chronic Kidney Disease (CKD)...
28 May 2015 | By Victoria White
TSRI scientists have been awarded nearly $2.2 million to advance understanding of IP6K1 and develop innovative approaches for the treatment of obesity...
