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Scientists uncover key that permits hepatitis C entry into cells
A new study has identified a key protein on the surface of the hepatitis C virus that interacts with a receptor found on human cells.
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Hepatitis C
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Hepatitis C drugs shown to boost remdesivir’s activity against SARS-CoV-2
Four hepatitis C drugs have demonstrated promise as boosters to increase the efficacy of remdesivir against SARS-CoV-2 by as much as tenfold.
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The development of biomaterial-based vaccine platforms against viruses
Recent years have seen an increase in the development of biomaterial and nanoparticle-based vaccine formulations. Sushma Kumari, Sonal Asthana and Kaushik Chatterjee from the Department of Materials Engineering at the Indian Institute of Science discuss why these materials have such high potential in the fight against infectious diseases.
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COVID-19 drug targets and cell-based assays
The length of time between the administration of a COVID-19 vaccine and evidence of a robust immune response to Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) means that treatments are still required. In this article, Sheraz Gul and Alp Tegin Sahin explore the various therapeutic targets that have been identified…
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New drug may boost vaccine responses in older adults
Researchers have found that spermidine can ramp up autophagy and boost T-cell function, potentially increasing the protective effects of vaccines in older adults.
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The latest pre-clinical HIV vaccine developments
This article lists three of the most recent advances in pre-clinical HIV research and vaccine development.
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Lysosomes key to coronavirus shedding, finds study
Scientists reveal that coronaviruses de-activate lysosomes before using them to exit infected cells and spread through the body.
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2020 Nobel Prize goes to discoverers of hepatitis C
The 2020 Nobel Prize in Physiology or Medicine has been bestowed upon researchers who helped identify the hepatitis C virus in the 1970s.
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Novel antiviral drug candidate blocks SARS-CoV-2 reproduction in cells
In human cells, a drug candidate called PF-00835231 has demonstrated success at blocking the reproduction of SARS-CoV-2.
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Study identifies eight novel coronavirus replication terminators
Scientists reveal eight new molecules, five of which are already US FDA-approved, that can block the polymerase reaction SARS-CoV-2 uses to replicate its genome.
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CD47 blockade could work as immunotherapy across multiple diseases
Researchers have demonstrated that blocking CD47-mediated signalling in mice can enhance the speed of pathogen clearance, presenting a new potential form of immunotherapy.
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Researchers develop open access database on macrolactones
A group of researchers has created a free library of 14,000 known macrolactones for other scientists to use in drug development.
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Better HIV, lupus and hep C treatments possible with malaria discovery
A new discovery on how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus.
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Gene transcription in CD8 T cells differentiates chronic from resolving HCV
Researchers have identified differences in gene transcription within key immune cells that may distinguish those individuals infected with HCV...
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Daiichi Sankyo to collaborate on drugs for neglected tropical diseases
Daiichi Sankyo has entered into a new joint research agreement with the Drugs for Neglected Diseases initiative (DNDi) with regard to a new research program, the Hit-to-Lead Project, with the aim of developing drug treatments for two neglected tropical diseases, leishmaniasis and Chagas disease.
