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Heart failure

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Novel gene therapy for heart failure moves closer to clinic

6 July 2021 | By Anna Begley (Drug Target Review)

New research by US institutions in pigs shows that knocking down a particular signalling pathway after heart failure renews heart tissue.

news

Drug target and candidate for paediatric heart failure identified

23 November 2020 | By Victoria Rees (Drug Target Review)

A group of researchers has found a drug candidate named TRV027 that can increase the cardiac contractility of neonatal mice.

someone holding chest having a suspected heart attack

news

Macrophages could be the target of novel heart attack therapies

3 February 2020 | By Hannah Balfour (Drug Target Review)

Research determined macrophages’ role in forming a permanent cardiac scar after a heart attack, the researchers suggest altering this behaviour may make the scar temporary and allow restoration of heart function.

news

Kinase identified as potential target for heart failure treatment

1 November 2019 | By Rachael Harper (Drug Target Review)

A new study has shown that restoring the amount of the kinase, HIPK2, in a kinase-depleted mouse model rescued it from heart failure and identifies HIPK2 as a novel regulator of heart failure progression.

news

Human stem cell combination could help damaged hearts live longer

6 August 2019 | By Rachael Harper (Drug Target Review)

A combination of heart cells derived from human stem cells could lead to developing a treatment for heart failure.

news

Hidden culprit in heart failure discovered

11 January 2019 | By Drug Target Review

A study has identified that PI3K alpha could be the culprit of heart failure, as it binds to gelsolin, suppressing it and preventing it from working...

news

Biomarker discovered for heart failure with preserved ejection fraction

1 November 2018 | By Drug Target Review

A biomarker has been discovered for the most common type of heart failure - heart failure with preserved ejection fraction...

news

Protein sequencing method could transform biological research

24 October 2018 | By Drug Target Review

A team of researchers have demonstrated a new way to sequence proteins that are much more sensitive than existing technology, identifying individual protein molecules rather than requiring millions of molecules at a time

news

3D map of CVD genetic interactions could aid future treatments

12 July 2018 | By Drug Target Review

A 3D map of genetic interactions in CVD could aid researchers investigating future treatments for heat attacks, heart failure and heart rhythm disorders.

news

Early stimulation improves performance of bioengineered human heart cells

5 April 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers are now able to use induced pluripotent stem cells to form a model of human adult-like cardiac muscle...

news

FUNDC1 protein in cardiac muscle cells linked to heart failure

6 December 2017 | By Dr Zara Kassam (Drug Target Review)

Reducing a protein found in the mitochondria of cardiac muscle cells initiates cardiac dysfunction and heart failure...

news

Heart failure is associated with loss of important gut bacteria

14 July 2017 | By Niamh Marriott (Drug Target Review)

In the gut of patients with heart failure, important groups of bacteria are found less frequently and the gut flora is not as diverse as in healthy individuals.

news

Scientists identify protein linked to chronic heart failure

30 May 2017 | By Niamh Marriott (Drug Target Review)

Researchers in Japan have identified a receptor protein on the surface of heart cells that promotes chronic heart failure.

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Heart failure