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Crohn’s disease

Holographic scan of intestines in woman's hands

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New Gut Cell Atlas reveals genetic origins of Crohn’s disease

10 September 2021 | By Anna Begley (Drug Target Review)

The Gut Cell Atlas comprises 428,000 cells in the gut and sheds light on the origin of Crohn’s disease and other intestinal diseases.

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Targeting TNF to treat Dupuytren’s disease, frozen shoulder and POCD

20 April 2021 | By Dr James Woody (180 Life Sciences)

Dr James Woody discusses off-patent indications for anti-TNF to address unmet patient needs in pain, inflammation and beyond.

news

New nanotherapy could potential treat Crohn’s disease in children

18 February 2021 | By Victoria Rees (Drug Target Review)

A novel nanotherapy can decrease intestinal inflammation and shrink lesions in rodent models of Crohn's disease, a study has shown.

news

Inflammatory bowel disease drugs could combat COVID-19, study suggests

6 November 2020 | By Victoria Rees (Drug Target Review)

Anti-inflammatory therapies for inflammatory bowel disease could aid recovery from COVID-19 as they target an enzyme involved in both diseases.

Abstract bubble background in lilac with a pink DNA strand

article

Advancing cell therapies with engineered Tregs

10 September 2020 | By Jason Fontenot (Sangamo Therapeutics)

Regulatory T cells (Tregs) play a key role in regulating our immune system and inflammatory processes. Sangamo Therapeutics is evaluating the potential of CAR-Tregs (Tregs genetically modified with a chimeric antigen receptor, or CAR) for the development of therapies for immunological diseases, such as Crohn’s disease and multiple sclerosis, as…

Mouse in lab - Translating novel drug success in animals to humans

article

Translating novel drug success in animals to humans

12 August 2020 | By Victoria Rees (Drug Target Review)

A team has developed a predictive tool called TransComp-R which could be used to reveal whether new drugs that have been effective in animals will have positive outcomes in humans.

article

Could novel sex-linked targets provide an autoimmunity therapy?

20 January 2020 | By Hannah Balfour (Drug Target Review)

Recent research into why autoimmune disorders affect women four times more frequently than men has revealed several novel therapeutic targets that may lead to the development of future treatments.

news

Bile acids acting as inflammation regulators may protect against IBD

6 January 2020 | By Hannah Balfour (Drug Target Review)

Research has found that bile acids, converted by gut microbes, act as inflammatory regulators in IBD by modulating the differentiation of T cells in the gut.

news

Potential treatment target identified for Crohn’s disease

9 August 2019 | By Rachael Harper (Drug Target Review)

Researchers have identified a pathway in the immune system activated in Crohn's disease which could lead to investigating new treatments.

news

Research identifies cells which contribute to inflammatory diseases

21 June 2019 | By Victoria Rees (Drug Target Review)

A new study has shown that there are two populations of cells in the gut which leads to drug development potential.

news

Inflammation inhibitor could be used to treat sepsis

19 November 2018 | By Drug Target Review

An inhibitor that stops the action of OGG1 signals, could potentially be used as a treatment for life-threatening Acute Respiratory Distress Syndrome...

news

miR-31 may help target treatments for Crohn’s patients

16 October 2018 | By Drug Target Review

Researchers have pinpointed a single molecule - microRNA-31 (miR-31) - the levels of which predict whether a patient has subtype 1 or subtype 2 of Crohn's disease...

news

Searching for targeted treatments for inflammatory diseases

7 February 2018 | By Drug Target Review

Scientists have identified identified key regulators that are essential for controlling the inflammatory response in Crohn’s disease and multiple sclerosis.

Discovery of novel targets and therapeutics for Crohn’s disease

news

Faulty gene could be responsible for some Crohn’s disease cases

19 December 2017 | By Steve Bremer (Drug Target Review)

Interaction between MDR1 gene and TH17 immune cells in the ileum could hold the key to Crohn's disease in some instances.

news

Engineering the gut microbiome may help treat Crohn’s disease

15 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have singled out a bacterial enzyme behind an imbalance in the gut microbiome linked to Crohn's disease...

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Crohn’s disease