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A new dawn in academic and pharma collaboration – a UK perspective

10 June 2015 | By Justin Bryans

Academia and pharma have always been uneasy bedfellows. There has in the past been tension between both caused by a range of issues that neither party was willing to try and resolve. However, there is a new impetus to solve these issues as both parties have started to realise that…

From hype to hope: challenging the norm in lead discovery

10 June 2015 | By Andy Merritt (MRC Technology Centre for Therapeutics Discovery)

From the beginning of time in the drug discovery world, the integration of disciplines has driven the identification of new lead molecules. Chemists, pharmacologists and biologists work together to understand a disease state and how to perturb that state back towards a normal healthy condition. However, in the early days…

Developing antibody therapeutics

10 June 2015 | By David Matthews (MRC Technology)

Monoclonal antibodies have come of age as therapeutics; there are now more than 30 antibodies on the market and over 200 in clinical trials. The attractions of therapeutic antibodies lie not only in their potential to make potent drugs but also their relative low risk in comparison to small molecule…

Novel approaches to targeting protein tyrosine kinases

10 June 2015 | By Carol Trim (Canterbury Christ Church University), Danielle McCullough (Canterbury Christ Church University)

Protein kinases, a diverse group of cellular enzymes, play fundamental roles in maintaining normal cellular functions such as growth, cell cycle control, proliferation, differentiation, migration, cellular survival and apoptotic induction.

Immune checkpoint inhibitors: targets on the horizon

19 April 2015 | By Kerstin Papenfuss (MRC Technology)

Immune checkpoint inhibitory antibodies have provided a great conceptual change in the field of immune-oncology. Rather than targeting the tumour directly, these novel drugs are aimed at preventing the interactions between the tumour and the immune system, which the cancer exploits to evade immune recognition...

LC3 – Autophagy’s achilles’ heel?

10 April 2015 | By Joana R Costa (TRRC University College London), Robin Ketteler (TRRC University College London)

Autophagy is a cellular homeostatic process regulating protein turnover as well as eliciting a stress response to starvation, chemical agents and pathogen infection. It has been implicated in the initiation and progression of several diseases, including neuro-degenerative disorders, Crohn’s disease, infections and cancer...

Data automation in large-scale omics-based biomedical research

10 April 2015 | By Sven Nahnsen (Quantitative Biology Center (QBiC))

Medicine and life sciences research are being revolutionised by major technological developments that have taken place over the past decade. High-throughput sequencers can now generate high-quality nucleotide sequence data at a small fraction of the cost compared to only a few years back...

Drug Target Review – Issue #1 2015

9 April 2015 | By J.R. Costa, J. Heintze, R. Ketteler, K. Papenfuss, C. Richards, S. Nahnsen, N. Graffman, P. Matz, W.Wruck, J. Adjaye, C. Williams, W. Fecke.

In this issue: Next-Generation Sequencing, Drug Targets, High Throughput Screening, Phenotypic Screening, Stem cells, Label-Free technologies and Assays...

NGS In-Depth Focus 2015

9 April 2015 | By Caroline Richards, Editor, Drug Target Review

In this NGS In-Depth Focus; How next-generation sequencing came to be, plus a brief history & Data management for large-scale NGS-based research projects...

Drug Targets In-Depth Focus 2015

9 April 2015 | By J.R.Costa, J.Heintze, R.Ketteler, S. Gul, Dr. T.Duensing, K.Papenfuss.

In this Drug Targets In-Depth Focus, we delve into the role of a key complex required for autophagosome maturation, the ATG4-ATG8 conjugation system, and we provide insight on some up-and-coming immune checkpoint inhibitors that are currently in clinical and preclinical development...

Academic high-throughput screening; Opportunities for change

9 April 2015 | By Tim Hammonds (Deputy Director of Discovery: CRT Discovery Laboratories)

Tim Hammonds from Cancer Research Technology Discoveries explains how academic HTS laboratories came into being and outlines the challenges facing the new HTS model...

The impact of phenotypic and functional screening in CNS drug discovery

9 April 2015 | By Christine Williams (UCB), Wolfgang Fecke (UCB)

Wolfgang Fecke and Christine Williams from UCB discuss the industry’s approach to drug discovery with costs escalating and output failing to achieve the corresponding increases in revenue...

Label-free technologies for monitoring drug interactions

9 April 2015 | By Jean-Francois Masson (Universite de Montreal and Centre for Self-Assembled Chemical Structures), Kristy McKeating (Universite de Montreal)

In his fascinating overview of label-free analysis, Dr. Masson introduces the four main label-free methods: physical, electrochemical, mass-based and optical techniques, before providing the reader with in-depth insight into the most common label-free technique within the pharmaceutical industry: surface plasmon resonance (SPR)...

Evaluation of a GADD45a-GFP human cell assay for rapid and reliable in vitro early genotoxicity screening

9 April 2015 | By Anne-Pascale Luzy (Galderma R&D), Guy Bouvier (Galderma R&D), Jean-Michel Linget (Galderma R&D), Nicolas Orsini (Galderma R&D)

This article evaluates a GADD45a-GFP human cell assay for rapid and reliable in vitro early genotoxicity screening...

The quest for accurate target validation

9 April 2015 | By Sheraz Gul (Fraunhofer-IME SP)

Preview of the upcoming foreword in our April issue, written by Sheraz Gul, Vice President and Head of Biology at Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Hamburg, Germany...

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