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NGS: enabling biomarker discovery at single-cell resolution

12 September 2018 | By Alka Saxena - National Institute for Health Research (NIHR) Guy’s and St Thomas’ Biomedical Research Centre

Investigations using Next-Generation Sequencing (NGS), once the domain of well-funded labs, have now become mainstream in the hunt for biomarkers for various disorders – ranging from breast and colon cancers to cardiomyopathies, diabetes, congenital cataracts, liver diseases and mitochondrial disorders. The NHS Executive (NHSE) has recently announced the use of…

Expert view: Challenges in flow cytometry

11 September 2018 | By John O'Rouke (Sartorius)

Flow cytometry is a powerful and flexible technology that delivers high content information from single cells and particles. Flow cytometry lends itself to a wide variety of applications, but traditional flow cytometry technologies are not widely adopted in the drug discovery industry due to limited throughput, slow sampling speeds and…

Yannick Marrari, Ph.D. Product Manager EMEA Cell Biology, Bio‑Rad

Expert view: Generate high‑content information using flow cytometry

11 September 2018 | By Yannick Marrari (Bio-Rad)

Flow cytometry has become a widely used technology in life science research since its development in the 1970s. It is also essential for many biopharmaceutical and biotechnology companies due to its proficiency in identifying biomarkers, finding new inhibitory antibodies, and assessing the efficiency of new pharmacological protocols.

Expert view: Tools for compliance with 21 CFR Part 11

11 September 2018 | By Maria C. Gentile (Beckman Coulter)

All computer systems that store data to make Quality decisions or data that will be reported to the FDA must be compliant with 21 CFR Part 11. The purpose of this law is to define the criteria under which electronic records and electronic signatures are considered trustworthy, reliable, and equivalent…

Expert view: Unravelling the complexities of GABAA subunit selectivity in drug discovery

10 September 2018 | By Dr. Davide Pau (SB Drug Discovery)

GABAA receptors represent a large and complicated family of ion channels that consist of at least 16 subunits (α1-6, β1-3, γ1-3, δ, ε, π, θ) that have been shown to be vital for the normal functioning of the brain. These inhibitory ligand-gated channels have been shown to beimportant in sedation,…

Yasmina Noubia Abdiche, PhD Chief Scientific Officer, Carterra® Inc.

Expert view: Screen everything. See everything.

10 September 2018 | By Yasmina Noubia Abdiche (Carterra)

Explore the full kinetic and epitope diversity of large antibody libraries with high throughput Array SPR (Surface Plasmon Resonance).

Upstream Bioprocessing In-Depth Focus 2018

10 September 2018 | By Drug Target Review

In this In-Depth Focus: upstream cell culture processes for the production of therapeutic proteins, the evolving role of three-dimensional in-vitro cell culture techniques in drug discovery, and human iPSCs-derived functional cells are revolutionising phenotypic drug discovery and development.

Flow Cytometry In-Depth Focus 2018

7 September 2018 | By Drug Target Review

Flow cytometry has played a key role in drug development, largely due to its ability to measure up to twenty parameters on single cells or particles suspended in a fluid stream. Conor Fitzpatrick discusses how the rise of high-throughput flow cytometry has contributed to the advancements in drug discovery...

NGS: hunting mysterious ‘Dark Matter Genome’ towards rewriting the rules of human genetic diseases

7 September 2018 | By Pushpanathan Muthuirulan - Harvard University Cambridge

Next generation sequencing (NGS) has revolutionised genomics research providing a wealth of genetic information of immense value to researchers. NGS technologies have been evolving over the last decade, leading to substantial improvement in understanding different biological systems from broader and deeper perspectives.1

How recent advances in flow cytometry can aid drug discovery

7 September 2018 | By Derek Davis - The Francis Crick Institute, Dr Rachael Walker - Babraham Institute

For many years, screening assays have been based on high-content imaging systems. However, recent advances in the field of flow cytometry have meant that flow-based assays are now more prevalent. The power of flow cytometry to utilise multiple lasers, multiple fluorochromes and multiplexed assays has meant that assays are not…

Expert view: Multiplexed screens in biologics discovery

7 September 2018 | By Thomas D. Duensing (IntelliCyt)

Biologics are the fastest growing class of therapeutics in the biopharmaceutical industry. A key driver for this growth is success with anti-cancer immunotherapeutics such as checkpoint modulation, adoptive cell therapy and bispecific T-cell engagers. While these approaches use different tactics to attack tumours, they often employ monoclonal antibodies to target…

Next-Generation Sequencing In-Depth Focus 2018

7 September 2018 | By Drug Target Review

In this In-Depth Focus: hunting mysterious ‘Dark Matter Genome’ towards rewriting the rules of human genetic diseases, and enabling biomarker discovery at single-cell resolution

Using bioactivity profiling to support the progression of phenotypic hits

7 September 2018 | By DiscoverX Corporation, Eurofins Pharma Discovery Services

This webinar, held on 28 June 2018, illustrated the optimisation of hits derived from a target-agnostic phenotypic screen, using a strategy based on combining bioactivity profiling and reference compound characterisation. Keynote speaker Arsenio Nueda, Head of Molecular Biology at Almirall, responded as follows to questions posed during the webinar.

The rise of high-throughput flow cytometry in drug discovery

7 September 2018 | By Conor Fitzpatrick

Flow cytometry has played a key role in drug development, largely due to its ability to measure up to twenty parameters on single cells or particles suspended in a fluid stream. Typically, cells are labelled with fluorescent markers and passed through a series of lasers, after which the resultant fluorescent…

Assays In-Depth Focus 2018

6 September 2018 | By Drug Target Review

This Assays In-Depth Focus looks at applications of high content screening in autophagy, and complex biology for the precision medicine era.

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