news
New study could lead to better treatments for autoimmune diseases
A study has found a new molecular process in mice that causes autoimmune diseases and has opened avenues for developing more effective autoimmune therapies.
List view / Grid view
Targets
news
Mechanism revealed which help pancreatic cancer cells avert starvation
A mechanism has been revealed that could be used to deny RAS mutant tumour cells (which is known to encourage the growth seen in pancreatic cancer patients) of a key survival mechanism.
news
Multi-omics approach yields novel insight for peanut allergies
Researchers in New York have identified novel genes associated with the severity of peanut allergies and noted how these genes interact with other genes during allergic reactions. The findings could lead to better treatments for peanut allergies.
news
Significant breakthrough made in Zika virus vaccine development
Researchers have developed a novel T cell-based vaccine against the Zika virus that has proved effective in mouse models.
article
Advances in mass spectrometry: unlocking the potential of chemical crosslinking as a structural biology tool
Chemical crosslinking coupled with mass spectrometry (XL-MS) has been used for many years to study protein structure and function. However, recent advances in MS technology, as well as crosslinking reagents and data analysis tools, mean the technique has truly come of age. Here, Albert JR Heck, Alexander Makarov, Henning Urlaub…
article
A novel approach to unravelling the mysteries of Alzheimer’s
The heterogenous and dynamic nature of protein aggregates makes them a particularly challenging class of structures to study. In this article, Professor Tuomas Knowles and Dr Sean Devenish present a novel approach to studying protein structures that could aid in understanding the complexities of Alzheimer’s disease and identify future therapeutic…
article
Hit-to-lead in neglected diseases – it’s a numbers game
The hit-to-lead journey can be a long endeavour, with many failures along the way. Nikki Withers spoke with DNDi ’s Discovery Director Dr Charles Mowbray to hear how the organisation is working to identify new leads with activity in animal models of neglected tropical diseases and the potential for further…
news
Extensive tumour protein analysis reveals new therapy targets
New research has categorised hundreds of cancers based on their common protein mutations, highlighting cell components and tumour microenvironments as possible new therapy targets.
article
Is a universal vaccine against cancer possible?
A new study has presented a potential strategy for a universal human cancer vaccine. This article delves into the researchers’ findings, exploring their methodologies and results.
news
Researchers find 150 possible inhibitors to fight Nipah virus
A group of scientists from India have used 3D imaging of the Nipah virus to discover potential inhibitors for the disease.
whitepaper
Application note: Custom Reagents & Contract Services
When your work demands unique reagents or scientific support, turn to the decades of product development legacy behind Bio-Techne’s trusted brands.
article
The implication of a dysfunctional proteasome regulator in neurodegenerative disease
Disrupted protein homeostasis from PI31 inactivation may initiate the process of neurodegeneration seen in Alzheimer’s, ALS and other similar diseases, says new research.
whitepaper
Poster: Advantages of recombinant antibody engineering
Antibodies play a critical role in diagnostics and therapeutics. In these, and other applications, performance and consistency are critical.
article
Expert view: Following mitchondrial substrate oxidation pathways to expose novel drug targets
Energy metabolism drives everything we do, so it is no surprise that the more we discover about these metabolic processes, the more we observe seamless integration with all core cellular functions.
article
Targets In-Depth Focus 2019
The articles in this In-Depth Focus explore a novel technique for studying protein aggregation in Alzheimer's research and explain how to maximise the potential of mass spectrometry.
