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Establishing Alpha CETSA HT in primary screening
7 May 2020 | By PerkinElmer
High-throughput screening (HTS) cascades have evolved to ensure that high quality hits can be identified from large screening collections.
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Structure of SARS-CoV-2 suggests reason for high infection rate, says study
Researchers have identified a structural loop in the SARS-CoV-2 S protein and a sequence of four amino acids that they say could help explain its high transmission rate.
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Researchers analyse SARS-CoV-2 genome, identifying 198 mutations
After analysing the genomic diversity in SARS-CoV-2 by screening over 7,500 viruses from infected patients, researchers have offered clues for COVID-19 drug development.
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Novel target for Sjögren’s Syndrome identified by researchers
A molecule called microRNA-744, which influences inflammation, has been revealed by researchers as a new drug target for Sjögren's Syndrome.
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Researchers reveal cryo-EM structure of remdesivir bound to SARS-CoV-2
A group of researchers has used cryo-EM to discover the structure of the remdesivir-bound RNA complex of SARS-CoV-2 and explain how the drug inhibits COVID-19 viral replication.
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Tregs produced by mesenchymal stromal cells with novel technique
By culturing blood cells with mesenchymal stromal cells (MSCs), researchers induced the production of cells with the same functionality as Tregs.
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Researchers suggest COVID-19 therapeutics needed to target blood vessel leakage
According to researchers, ACE2 receptors disappear from lung cells during COVID-19, allowing small blood vessels to leak at the site of infection, presenting a new drug target.
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Silicates from soil aid in triggering blood clotting, reveal researchers
A new study has revealed that the presence of soil in wounds helps to activate a blood protein known as coagulation Factor XII, leading to clotting.
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AI platform developed to rapidly identify treatment regimens for infections, including COVID-19
A new AI tool has been created by researchers to identify the best treatment courses and doses for bacterial or viral infections, such as COVID-19.
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Larval protein could suppress inflammatory reactions, say researchers
A study has revealed that a protein of roundworm larvae which needs to invade the intestines of rodents to survive could be used to control inflammation.
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Researchers identify lead compounds for treatment of telomere diseases
Researchers investigating telomere dieases such as dyskeratosis congenita have found lead compounds that reverse cellular ageing in mouse models of the condition.
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Novel antibody treatment for OCD demonstrates efficacy in mice
Researchers who administered an antibody to neutralise an OCD-associated protein in mice found it reduced their anxious behaviours.
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Universal Ebola vaccine shows promise in pre-clinical trials
An Ebola vaccine that has been tested in animals could potentially be used to neutralise four species of the virus, say the researchers.
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High-throughput screening for antibody-based drugs
A collaboration between academia and industry has produced an assay and new screening technique which utilises directed evolution for the discovery of antibody-based drugs.
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Consortia of microbes could reduce inflammation and promote colon health, say researchers
A study has shown that two products of bacterial bile metabolism boost the conversion of precursor T cells into peripheral Tregs, which suppress chronic inflammation in the colon.
