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Inhibiting enzyme could provide strategy to halt glioblastoma growth

15 February 2021 | By Victoria Rees (Drug Target Review)

A study has shown that inhibiting the enzyme PRMT5 can suppress the growth of glioblastoma cells in pre-clinical studies.

news

STING activation reduces graft-versus-host disease in mouse model

12 February 2021 | By Victoria Rees (Drug Target Review)

A team has shown that STING activation is a new molecular target in the fight against graft-versus-host disease (GVHD).

news

Scientists reveal four discoveries about early SARS-CoV-2 infection

11 February 2021 | By Victoria Rees (Drug Target Review)

Researchers studying SARS-CoV-2 at the individual cellular level have made four major discoveries about early infection from the coronavirus.

news

Scientists discover new promising target for diabetes treatment

28 January 2021 | By Victoria Rees (Drug Target Review)

Researchers have found a druggable insulin inhibitory receptor named inceptor that could provide a drug target for diabetes.

news

Novel compound named BC1618 could serve as new diabetes drug

27 January 2021 | By Victoria Rees (Drug Target Review)

Researchers have identified a new compound that improved responses to insulin and treated diabetes in obese mouse models.

news

Two novel molecules to potentially combat asthma discovered

26 January 2021 | By Victoria Rees (Drug Target Review)

Researchers have discovered that giving L-tyrosine and PCS to mice prevents lung inflammation and an allergic asthma response.

news

Researchers develop novel way to identify new cancer drugs

26 January 2021 | By Victoria Rees (Drug Target Review)

A team has developed a new way to discover peptide therapeutics that inhibit HDAC enzymes and are effective against cancer.

news

Oral drug blocks SARS-CoV-2 transmission in ferrets, researchers find

4 December 2020 | By Victoria Rees (Drug Target Review)

A team has found that their drug Molnupiravir (MK-4482/EIDD-2801) acts as an antiviral against SARS-CoV-2 in pre-clinical studies.

Nurse in gown, face mask and hloves holding a nasal swab and inserting it into a tube labelled 'COVID-19 Test'

news

New virus-like probes could make COVID-19 tests more accurate and reliable

2 December 2020 | By Hannah Balfour (Drug Target Review)

The novel probes, known as positive controls, could make it easier to validate rapid, point-of-care diagnostic tests for COVID-19 across the globe.

article

Targets In-Depth Focus 2020

8 September 2020 | By Drug Target Review

This in-depth focus includes articles on the importance of a novel target to treat M. tuberculosis infections and how recently identified interactions between the SARS-CoV-2 Spike protein and host epithelial cells could be used in the development of COVID-19 therapeutics.

news

Researchers treat diffuse intrinsic pontine glioma in mice

17 August 2020 | By Victoria Rees (Drug Target Review)

Researchers have treated diffuse intrinsic pontine glioma (DIPG), a fatal childhood brain cancer, in mice by targeting two metabolic pathways.

news

Atomic-scale details of SARS-CoV-2 Spike protein from vaccine obtained

11 August 2020 | By Victoria Rees (Drug Target Review)

The SARS-CoV-2 Spike protein from a COVID-19 vaccine candidate has been characterised by researchers, supporting the neutralising antibody response it elicits.

news

New chemical screening method could reveal molecular glue degraders

4 August 2020 | By Victoria Rees (Drug Target Review)

A phenotypic chemical screen has been developed that could be used to discover molecular glue degraders which induce the degradation of target proteins.

news

Researchers identify sEH enzyme as novel Alzheimer’s drug target

27 July 2020 | By Victoria Rees (Drug Target Review)

A team has shown that inhibiting the soluble epoxide hydrolase (sEH) enzyme in murine models can prevent the cognitive deterioration associated with Alzheimer's.

news

Imaging and machine learning system created to discover tuberculosis drugs

24 July 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed MorphEUS, a technology to identify new drugs that combat M. tuberculosis by revealing how compounds destroy the bacteria.

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Target Validation