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Elderly woman putting last piece of brain shaped puzzle

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Scientists explore CA2 neuron mitochondria for memory loss targets

10 November 2021 | By Anna Begley (Drug Target Review)

The team will receive $2 million over five years to investigate the CA2 brain region for the development of neurological therapies.

news

Novel intestine chip enables effective in vitro study of COVID-19 therapies

10 November 2021 | By Anna Begley (Drug Target Review)

The intestine chip was infected with a coronavirus to test a variety of drugs, presenting a new method to investigate COVID-19 treatments.

news

Soluble fibrinogen a potential target for neurodegeneration

9 November 2021 | By Anna Begley (Drug Target Review)

In a pre-clinical study, fibrinogen increased the death of mouse brain neurons, suggeting fibrin can have similar toxic effects on neurons.

news

IL-36Ra discovery may help heal skin wounds from ischemia reperfusion

8 November 2021 | By Anna Begley (Drug Target Review)

The absence of interleukin-36 receptor antagonist (IL-36Ra) significantly slowed down wound healing in ischemia-reperfusion injuries in mice.

news

ABI3 gene may be the key to new Alzheimer’s disease therapies

8 November 2021 | By Anna Begley (Drug Target Review)

The study found that deleting the ABI3 gene in mice increased plaques and inflammation in the brain, suggesting avenues for new treatments.

news

Alterity’s ATH434 improves Parkinson’s-related gastrointestinal dysfunction

4 November 2021 | By Anna Begley (Drug Target Review)

ATH434 reversed some of the gastrointestinal damage to the enteric nervous system associated with Parkinson's disease in a pre-clinical study.

Blood vessel with flowing red blood cells inside

news

Researchers identify COVID-19 proteins that cause blood vessel damage

3 November 2021 | By Anna Begley (Drug Target Review)

Scientists revealed five proteins that cause blood vessel damage in COVID-19 patients, potentially leading to new drug targets.

news

Monoclonal antibodies prevent COVID-19 inflammation in macaques

2 November 2021 | By Anna Begley (Drug Target Review)

Neutralising monoclonal antibodies protected aged macaque monkeys from SARS-CoV-2 and reduced inflammation, including in cerebrospinal fluid, a new study has shown.

news

Pathway and enzyme responsible for CKD thrombosis identified

2 November 2021 | By Anna Begley (Drug Target Review)

Scientists have discovered a novel pathway and enzyme that causes thrombosis in chronic kidney disease (CKD) patients, indicating a new drug target.

MRI scan of brain with Alzheimer's disease

news

Scientists eliminate key Alzheimer’s feature in animal model

1 November 2021 | By Anna Begley (Drug Target Review)

Turning off NHE6 in mice in pre-clinical studies prevented amyloid beta aggregation, a key feature of Alzheimer's disease, pointing to new therapies.

news

NMR method could uncover details of cancer and neurodegeneration development

1 November 2021 | By Anna Begley (Drug Target Review)

Scientists have used nuclear magnetic resonance (NMR) spectroscopy to investigate the protein p53, which they say could advance cancer studies.

Antibiotic resistant bacteria in biofilm

news

Machine learning models predict antibiotic resistance spread

29 October 2021 | By Anna Begley (Drug Target Review)

Scientists have used several machine learning models to predict bacterial gene exchange, which could reveal novel antibiotic targets.

Red blood cells flowing with too many white blood cells, indicating leukaemia

news

Albert Einstein researcher receives NIC award to study two blood cancers

28 October 2021 | By Anna Begley (Drug Target Review)

Professor Ulrich G Steidl received the National Institute of Cancer's Outstanding Investigator Award to study myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML).

T cell lymphocyte with receptors to kill cancer cell in cancer i

news

Raman spectroscopy used to determine immunotherapy effectiveness

28 October 2021 | By Anna Begley (Drug Target Review)

Researchers used Raman spectroscopy to monitor immunotherapy response in mice, potentially improving cancer treatments in the future.

Mouse on lab tubes with DNA molecule in background

news

Experimental mouse model reveals potential progeria treatment strategy

27 October 2021 | By Anna Begley (Drug Target Review)

Scientists have found that Hutchinson-Gilford Progeria Syndrome (HGPS) can be prevented with treatments targeting the cardiovascular system using a novel mouse model.

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