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Second mechanism of action discovered for COVID-19 drug remdesivir

11 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have found that a metabolite of remdesivir potentially targets a SARS-CoV-2 protein involved in suppressing the host cell's defence response.

news

Structure of DNA actively involved in genome regulation, study shows

10 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.

news

Genetic profile of skeleton osteocytes mapped for first time

6 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have revealed which genes are switched on or off in osteocytes, a bone cell found in the skeleton.

news

Novel nanopore platform developed to sequence DNA

30 April 2021 | By Victoria Rees (Drug Target Review)

Scientists have created a new nanopore sequencing platform that can detect the presence of the nucleobases of DNA.

news

New mRNA delivery system effectively protects neurons in rats from ischemia

9 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that an mRNA delivery system can be used to produce the BDNF protein in rats to protect neurons from ischemia.

news

New single-cell transcriptomics method does not put cells under stress

8 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have created a new single-cell transcriptomics approach that cryopreserves cells, limiting the stress they are put under.

news

Team reveals miR-29 as regulator of processes for normal brain maturation

7 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that miR-29 can control brain maturation in mammals, presenting a target for autism, epilepsy and other conditions.

article

How RNA therapeutics can be used to treat retinitis pigmentosa

5 April 2021 | By Sahm Nasseri (PYC Therapeutics)

Sahm Nasseri discusses promising pre-clinical results of an RNA-based therapeutic developed to treat retinitis pigmentosa type 11.

Effectiveness of CRISPR‑Cas9 using pools of synthetic crRNAs in high-content analysis screening experiments

whitepaper

Application note: Effectiveness of CRISPR‑Cas9 using pools of synthetic crRNAs in high-content analysis screening experiments

31 March 2021 | By Horizon Discovery

In this application note, discover how pools of synthetic crRNAs can produce a phenotype as strong as, or stronger, than any one of the component crRNAs in arrayed CRISPR screening experiments.

news

‘Zinc finger’ gene therapy could help to treat Alzheimer’s disease

23 March 2021 | By Victoria Rees (Drug Target Review)

Promising results have been shown in an animal model of Alzheimer's disease treated with zinc finger protein transcription factors.

news

Researchers gain insight into metabolic pathways hijacked by SARS-CoV-2

16 March 2021 | By Victoria Rees (Drug Target Review)

SARS-CoV-2 diverts building blocks from glucose production to the assembly of purine bases, researchers have found.

news

RNA protein shown to protect telomeres and support cancer proliferation

15 March 2021 | By Victoria Rees (Drug Target Review)

A team has revealed a function of ADAR1, responsible for RNA editing, discovering an isoform used for cancer growth, making it a drug target.

news

Researchers study iPSCs to uncover genetic causes of disease

5 March 2021 | By Victoria Rees (Drug Target Review)

Sequencing and transcriptome data on iPSCs has been used to identify correlations between genetic variants and expression patterns.

news

Computational method used to quantify tRNAs in any organism

1 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a new technique called mim-tRNAseq to measure, map and analyse tRNAs in cells, providing insight into disease.

news

New fluorescence imaging method enables live RNA visualisation

26 February 2021 | By Victoria Rees (Drug Target Review)

A fluorescence imaging technique has allowed scientists to observe RNA in real time using single-molecule localisation microscopy.

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