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Splicing-variant detection method identifies biomarkers for HCC
Researchers report a method for identifying splicing-based biomarkers for hepatocellular carcinoma....
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Scientists discover critical molecular biomarkers of preeclampsia
Small non-coding RNAs may be used to devise a diagnostic blood test for pregnant women...
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CRISPR/Cas9 variant holds promise for Huntington’s disease treatment
Improvements to gene-editing techniques hold promise for inactivating the defective gene responsible for this as-yet incurable disease...
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Single-cell RNA sequencing provides molecular atlas to study brain diseases
Researchers have detailed a molecular atlas of the cells that form the brain's blood vessels and the life-essential blood-brain barrier providing clues to which cell types are involved in different diseases...
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Huntington’s disease provides new cancer weapon
Scientists have discovered why Huntington's is so toxic to cancer cells and harnessed it for a novel approach to treat cancer...
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SMi’s 9th annual RNA Therapeutics conference will take place in just 2 weeks!
Presenting issues and real-life examples within the RNA space, SMi welcome insights and discussions into new technologies for single-stranded RNA, epigenetics to develop first-in class drugs in oncology, patenting RNA Therapeutics and exploring the latest developments in delivery systems, including Exosomes and Nanocomplexes. Read on for your exclusive discount to…
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Scientists uncover the secret to how piRNAs defend the genome
Researchers from the University of Chicago have uncovered the mechanism by which small RNA molecules (piRNAs) locate and silence foreign invading genes, whilst avoiding ‘self’ genes.
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Innovation – Ingrained in the DNA of Ion Torrent products
For Thermo Fisher Scientific, 2018 brings with it a suite of new sequencing solutions that continue to promote application flexibility and throughput scalability for oncology, reproductive health, inherited and infectious disease research.
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TIMP-1 protein plays role in reducing cancer’s spread
Researchers have found that the TIMP-1 molecule that helps regulate gene expression plays a big role in keeping us safe from the machinations of cancer...
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Pixelated gene expression tool provides fast accurate results for RNA analysis
Researchers have demonstrated how a pixelated gene expression tool can accurately measure RNA levels more quickly than existing methods allow.
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Discovery into cells’ energy supply could lead to targeted cancer treatment
Scientists have made a significant breakthrough in understanding how the molecular machines that produce key proteins are cleaned and maintained. ..
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Heart-muscle patches improve heart attack recovery
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals the patches significantly improved recovery from heart attack injury...
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Proteogenomics research – on the frontier of precision medicine
Proteogenomics is the systematic and comprehensive integration of proteomics with genomics and transcriptomics. Proteogenomics is opening new hallmarks in biomedical research. Recently, several studies have demonstrated the relevance of proteogenomics in cancer research. This article provides a brief review of the advantages of proteogenomics in precision medicine.
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Using bioinformatics sequence similarities to optimise repurposing activities
A significant amount of selectivity and potency data originating from screening of drug targets is generated each year and deposited in public databases. This can be exploited to accelerate drug discovery, in particular, for a variety of repurposing activities...
whitepaper
Application note: KingFisher sample purification system
Next generation sequencing sample preparation on the KingFisher platform...
