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The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…
Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis...
In this issue: Omics-informed drug target discovery in combating emerging infectious diseases, measuring intracellular ATP levels to access compound-mediated cellular toxicity, and turning organoids into physiologically relevant high-content assays for drug discovery.
Scientists in Australia have discovered how the most important gene in preventing cancer, TP53, is hampered in its tumour-fighting efforts by mutant p53 proteins.
Researchers at Tokyo University have investigated the role of the Atg2 protein in the process of autophagy to aid drug discovery into neurodegeneration...
Single molecule fluorosequencing could revolutionise the way researchers analyse disease, with the method enabling the investigation of single cells...
Since the development of the so-called soft ionisation techniques: electrospray ionisation and matrix-assisted laser desorption and ionisation in the 1980s and early 1990s and the development of high-resolution mass spectrometers, mass spectrometry (MS) has come to the fore in studying complex biological systems...
A study indicates the possibility of using tiny vesicles derived from human immature red blood cell as a vaccine platform...
Researchers have deployed a bacterial import signal in order to deliver Nurr1 into cells...
Researchers have identified a potential treatment that will be a foundation for developing drugs for various genetic disorders...
Researchers at the University of Florida have discovered that a modified version of an important immune cell protein, TLR5, could be used to treat Alzheimer's disease.
Researchers in Spain have identified a means of classifying patients with the most aggressive form of breast cancer - triple negative breast cancer; providing meaningful prognosis for the first time.
A protein known to drive nerve cell survival in the brain and spinal cord may also protect failing hearts in children and young adults with DMD...
The components of the immune system that trigger allergic reactions may also help protect the skin against cancer, suggest new findings...
