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Proteomics

computer image of a dark grey ball of cells, a 'tumour', covered in blood vessels withing pink tissue

news

Novel antibody slows cancer growth and metastasis in mice

27 April 2020 | By Hannah Balfour (Drug Target Review)

The antibody targets a cell receptor in blood vessels and slowed breast and lung cancer growth as well as metastasis in murine models.

news

Cell types enabling initial COVID-19 infection identified by researchers

27 April 2020 | By Victoria Rees (Drug Target Review)

An international group of researchers has revealed that goblet and ciliated cells in the nose have high levels of the entry proteins for the SARS-CoV-2 coronavirus.

patient on a ventilator surrounded by monitors and doctors wearing personal protective equipment

news

Hyperferritinaemia could be causing severe COVID-19

27 April 2020 | By Hannah Balfour (Drug Target Review)

Professor Yehuda Shoenfeld suggests hyperferritinaemia, a condition caused by high ferritin levels, may be causing the severe COVID-19 symptoms.

COVID-19 coronavirus particles in grey surrounding red lungs on a black background

news

COVID-19 research indicates SARS-CoV-2 exploits immune defences to drive infection

22 April 2020 | By Hannah Balfour (Drug Target Review)

A new study has revealed that less than 10 percent of respiratory and intestinal cells are susceptible to SARS-CoV-2 infection and expression of ACE2 receptors is driven by the body's immune response.

news

Novel antibody treatment for OCD demonstrates efficacy in mice

22 April 2020 | By Victoria Rees (Drug Target Review)

Researchers who administered an antibody to neutralise an OCD-associated protein in mice found it reduced their anxious behaviours.

dendritic cell presenting antigens to T cells with cut away of the T cell receptor and antigen on MHC binding

news

High-throughput protocol for producing tetramer assay probes used to investigate COVID-19

21 April 2020 | By Hannah Balfour (Drug Target Review)

The developers of a novel method to create immunological assay probes for screening T cells has leveraged their new protocol against COVID-19.

strands of DNA contained withing blue and white capsules, on a dark blue background

news

Novel gene promoters could improve gene therapies for neurological diseases

20 April 2020 | By Hannah Balfour (Drug Target Review)

Novel promoters based on those in the herpes viruses, enabled delivery of larger genes and increased the period they were active in the nervous system.

news

Specialised proteins could halt cytokine storms in COVID-19 patients

17 April 2020 | By Victoria Rees (Drug Target Review)

Researchers who developed modified proteins say this could be used in the fight against COVID-19, by tackling cytokine storms.

stages of plant growth from small shoot on the left to larger leafed plant on the right

news

Plant bio-factories contributing to the COVID-19 fight

15 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers have made the genome of the Nicotiana benthamiana plant, a commonly used bio-factory organism, public to aid in COVID-19 vaccine production.

Cartoon of people of various races/religions/ethnicities all wearing white surgical masks to protect against COVID-19

news

Researchers release 21 openly available SARS-CoV-2 genome sequences

14 April 2020 | By Hannah Balfour (Drug Target Review)

Austrian researchers reveal the first 21 SARS-CoV-2 viral genomes as part of their project to aid in international understanding of how the virus causing COVID-19 mutates.

news

Main COVID-19 protease revealed, enabling screening of potential drugs

14 April 2020 | By Victoria Rees (Drug Target Review)

Chinese researchers who determined the crystal structure of the COVID-19 protease Mpro used this information to screen over 10,000 compounds to combat the coronavirus.

artist impression of the anatomy of the lungs with bronchi and bronchioles highlighted in red

news

Human lung epithelium model being tested as a platform for COVID-19 research

9 April 2020 | By Hannah Balfour (Drug Target Review)

The developers of the lung epithelium model plan to investigate whether SARS-CoV-2 can infect and replicate in the model to assess whether it could be used in the fight against COVID-19.

news

Scientists identify fusion peptide as promising COVID-19 drug target

8 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers working on related coronaviruses SARS and MERS have identified the membrane fusion peptide on the Spike protein as a possible drug target for SARS-CoV-2, the virus causing COVID-19.

video

Video: Increased reproducibility with KingFisher™ instruments

8 April 2020 | By Thermo Fisher Scientific

ESHG 2019 Conference Presentation: Using KingFisher™ to increase reproducibility in new applications using challenging samples.

news

Researchers reveal how SARS antibody binds to COVID-19 coronavirus

7 April 2020 | By Victoria Rees (Drug Target Review)

The interaction between a SARS antibody called CR3022 and the COVID-19 coronavirus has been mapped by researchers, revealing a viral vulnerability.

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Proteomics