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CRISPR approach could limit toxicity of CAR-T therapy in AML
New study uses CRISPR/Cas9 to make CD33 CAR T cells cancer-specific...
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Proteogenomics
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Modified PIP protein differentiates between cancerous and non-cancerous cells
A discovery sheds light on how cancerous cells differ from healthy ones and could lead to the development of new strategies for therapeutic intervention for difficult-to-treat cancers...
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EGFL7 protein provides a new treatment approach for MS
Researchers have discovered that the EGFL7 protein inhibits the migration of immune cells into the brain...
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Scientists create complex transmembrane proteins from scratch
Advance paves the way for the design of transmembrane proteins with useful new functions...
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Thorase protein may be linked to schizophrenia
Epilepsy drug reverses anti-social behaviours in mice with genes that produce variant proteins...
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Proteogenomics research – on the frontier of precision medicine
Proteogenomics is the systematic and comprehensive integration of proteomics with genomics and transcriptomics. Proteogenomics is opening new hallmarks in biomedical research. Recently, several studies have demonstrated the relevance of proteogenomics in cancer research. This article provides a brief review of the advantages of proteogenomics in precision medicine.
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Drug Target Review – Issue #4 2017
Issue 4 of Drug Target Review looks at artificial intelligence in drug discovery and features In-Depth Focuses on Screening, Hit to Lead and Informatics.
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APC protein affects immunity by preventing pre-cancerous inflammation
Mutations in the APC gene, harm the immune system, leaving it unable to tackle inflammation thereby favouring the development of cancer...
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Bacterial proteins show promise for a gonorrhoea vaccine
Researchers have identified a pair of bacterial proteins that show promise as the basis for a gonorrhoea vaccine...
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Discovery improves understanding of cellular ageing and cancer development
A team of researchers has discovered the role of the protein ZBTB48 in regulating both telomeres and mitochondria, key players involved in cellular ageing.
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Drug developed for arthritis could be first to stop heart valve calcification
The first drug to treat calcification of heart valves may be one originally designed for rheumatoid arthritis.
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Alzheimer’s, Parkinson’s, and Huntington’s diseases share common crucial feature
A study has found that abnormal proteins found in Alzheimer's disease, Parkinson's disease, and Huntington's disease all share a ability to cause damage...
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DFG €66 million funding for 15 new research training groups
The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing 15 new Research Training Groups to further support early research...
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Spread of tau protein measured in the brains of Alzheimer’s patients
In a new study researchers measured how deposits of the pathological protein tau spread through the brain over the course of Alzheimer’s disease.
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A new bioinformatics tool to decipher evolutionary biology
Understanding evolution is one of the cornerstones of biology - evolution is, in fact, the sole explanation for life's diversity on our planet. Based on the evolution of proteins, researchers may explain the emergence of new species and functions through genetic changes or how enzymes with novel functions might be…
