Protein

CAR T-cell therapy could be harnessed to treat heart disease

11 September 2019 | By Rachael Harper (Drug Target Review)

New study finds immunotherapy reduces cardiac fibrosis and restores heart function in mice after cardiac injury.

Inhibiting kinase improves arrhythmogenic cardiomyopathy symptoms

5 September 2019 | By Victoria Rees (Drug Target Review)

A research team has found that blocking a particular kinase in a mouse model of arrhythmogenic cardiomyopathy led to improved survival rates.

Membrane protein function behind epilepsy discovered

30 August 2019 | By Victoria Rees (Drug Target Review)

Researchers have revealed the 3D structure of a membrane protein which plays a role in the development of conditions such as epilepsy and blindness.

Muscular dystrophy mutation shown to protect against HIV-1

29 August 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered that a rare muscle disease causes resistance to HIV-1 infection in patients, providing insight into potential therapies.

Structure of crucial metabolic enzyme revealed by high-end microscopy

29 August 2019 | By Rachael Harper (Drug Target Review)

Scientists reveal the atomic structure and regulative mechanism of the metabolic enzyme transhydrogenase.

Blocking new protein helps immune system to fight cancer

28 August 2019 | By Rachael Harper (Drug Target Review)

A protein discovery could lead to a new and highly potent immune-therapeutic drug for the eradication of cancers using natural killer cells.

Telomere damage in cells is caused by runaway mitochondria

27 August 2019 | By Rachael Harper (Drug Target Review)

Using new technology researchers have shown that sick mitochondria pollute the cells they are supposed to be supplying with power.

Study uncovers key processes behind MYC cancer gene

26 August 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered that MYC cancers use the cell’s machinery to make lipids and identified a lipid signature, which could be exploited in the development of new therapies.

Succinate in cystic fibrosis lungs feeds deadly bacteria

23 August 2019 | By Rachael Harper (Drug Target Review)

Targeting a deadly bacteria's use of succinate in the lungs could control infection and improve the health of people with cystic fibrosis.

Gene linked to rare disorder also regulates key enzyme in Alzheimer’s

22 August 2019 | By Rachael Harper (Drug Target Review)

A gene associated with a rare balance disorder also regulates the behaviour of an enzyme that increases the risk for Alzheimer's disease.

New drug target for glioblastoma identified by study

21 August 2019 | By Rachael Harper (Drug Target Review)

A new drug target for treating glioblastoma has been identified from a cellular pathway found to contribute to the spread of glioma stem cells.

Tosoh Bioscience

Genes responsible for gender differences in tumours identified

19 August 2019 | By Rachael Harper (Drug Target Review)

A new study has identified possible regulators that determine differences in cancer tumours between genders.

Electrical channels in retina could play role in degenerative diseases

16 August 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered electrical channels important in sensory cell renewal which could be studied further to develop therapies for retinal diseases.

Genes linked to Alzheimer’s risk have been identified

15 August 2019 | By Nic Losardo (Drug Target Review)

Two genes that influence risk Alzheimer's disease could provide scientists with new targets for delaying the onset of the condition's symptoms.