news Masitinib found to be an effective COVID-19 treatment in mouse model 3 August 2021 | By Anna Begley (Drug Target Review) Scientists from the University of Chicago discovered that the drug masitinib inhibits the replication of SARS-CoV-2 in mice.
news Researchers develop toxicity test for placenta and embryos 22 July 2021 | By Anna Begley (Drug Target Review) A Swiss team have created a laboratory test that incorporates the placenta into embryotoxicity assessments without damaging foetuses.
news Screening method finds potential drugs to repurpose against COVID-19 13 July 2021 | By Anna Begley (Drug Target Review) Researchers have identified 38 drugs that could be repurposed to treat COVID-19 through a strategy involving virtual screening and cell-based assays.
news Synthetic antibody treats congenital myasthenia in mice 28 June 2021 | By Victoria Rees (Drug Target Review) Researchers have designed an antibody that attaches to MuSK, which prevented early lethality of mice with congenital myasthenia.
news Study of liver cancer reveals MAGEA3 gene as new drug target 25 June 2021 | By Victoria Rees (Drug Target Review) A study has shown that blocking the gene expression of MAGEA3 in liver cancer cells prevents the tumour from proliferating.
news Nanodecoy therapy neutralises SARS-CoV-2 in macaques 18 June 2021 | By Victoria Rees (Drug Target Review) Lung spheroid cells can act as nanodecoys for the SARS-CoV-2 Spike protein to bind to, according to a new pre-clinical study.
news Senolytic drugs reduce COVID-19 symptoms in mice, study shows 9 June 2021 | By Victoria Rees (Drug Target Review) In pre-clinical studies, senolytic drugs were found to reduce inflammation and death from COVID-19 in older mice.
news Avocado compound targets enzyme critical to leukaemia cell growth 30 April 2021 | By Victoria Rees (Drug Target Review) The fat molecule avocatin B, found in avocados, was shown to inhibit VLCAD, an enzyme vital for leukaemia cell metabolism.
news Inhibiting METTL3 enzyme combats acute myeloid leukaemia in mice 27 April 2021 | By Victoria Rees (Drug Target Review) Scientists have developed a drug called STM2457 which inhibits a key enzyme involved in acute myeloid leukaemia.
news DNA vaccine protects non-human primates against MERS, study shows 23 April 2021 | By Victoria Rees (Drug Target Review) A candidate vaccine has shown potential against MERS in non-human primates, when administered intradermally.
news Experimental drug shown to reverse effects of Alzheimer’s in mice 23 April 2021 | By Victoria Rees (Drug Target Review) Oral doses of a new drug named CA administered to mouse models led to improvements in Alzheimer's disease, including memory.
news Team develops cerebral organoid system to screen for CJD drugs 20 April 2021 | By Victoria Rees (Drug Target Review) Researchers have developed their previously created brain organoid to test for potential drugs against Creutzfeldt-Jakob disease (CJD).
news MK-4482 antiviral effective against SARS-CoV-2 in hamster study 19 April 2021 | By Victoria Rees (Drug Target Review) The drug MK-4482 decreased viral levels in the lungs of hamsters treated for SARS-CoV-2 infection, researchers have shown.
news Novel opioid could provide pain relief alternative to fentanyl 2 April 2021 | By Victoria Rees (Drug Target Review) NFEPP, a new opioid, inhibited colon pain in mice with colitis but did not cause the side effects associated with use of fentanyl.
news High-CBD cannabis extracts could provide COVID-19 treatment 9 March 2021 | By Victoria Rees (Drug Target Review) Cannabidiol's (CBD) anti-inflammatory properties could be harnessed to treat or prevent COVID-19, according to a new study.
