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Pharmacology

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Alterity’s ATH434 improves Parkinson’s-related gastrointestinal dysfunction

4 November 2021 | By Anna Begley (Drug Target Review)

ATH434 reversed some of the gastrointestinal damage to the enteric nervous system associated with Parkinson's disease in a pre-clinical study.

news

PANACEA consortium to increase global access to NMR spectroscopy

26 October 2021 | By Anna Begley (Drug Target Review)

The Pan-European Solid-State NMR Infrastructure for Chemistry-Enabling Access will offer researchers access to over 30 NMR spectrometers.

news

Psilocybin spurs growth of neural connections lost in depression in vivo

1 October 2021 | By Victoria Rees (Drug Target Review)

Research from Yale University has shown that psilocybin, given to mice, triggered an increase in connections between neurons.

Yellow antidepressant pills with smiley faces drawn on

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Antidepressants inhibit growth of pancreatic and colon cancers in mice

29 September 2021 | By Anna Begley (Drug Target Review)

Scientists have discovered that approved antidepressant drugs cause immune cells to recognise and eliminate tumour cells in mouse models.

Degeneration of dopaminergic neuron, indicating onset of Parkinson's disease

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NINDS awards Sinopia $3.3m for development of Parkinson’s drug candidate

29 September 2021 | By Anna Begley (Drug Target Review)

Sinopia has been awarded a $3.3 million Fast-Track SBIR grant to fund the study for its small molecule candidate for Parkinson’s disease.

Shaky image of hand holding glass of water, indicating Parkinson's disease

news

Promising pre-clinical data announced for Parkinson’s drug

27 September 2021 | By Anna Begley (Drug Target Review)

Stealth BioTherapeutics reported positive data from a pre-clinical study evaluating SBT-272 in a murine model of Parkinson's disease.

news

Sanofi acquires Translate Bio for mRNA therapeutic development

24 September 2021 | By Anna Begley (Drug Target Review)

Sanofi has completed the acquisition of mRNA therapeutics company Translate Bio for a total of approximately $3.2 billion.

news

MEPs demand action plan to end animal testing in Europe

16 September 2021 | By Anna Begley (Drug Target Review)

MEPs have requested that the EU adopts new plans to phase out the use of animals in scientific research and testing, focusing on alternatives instead.

Brain with Alzheimer's disease - gene therapies

article

Delivering gene therapies to the brain to treat Alzheimer’s

31 August 2021 | By Victoria Rees (Drug Target Review)

Dr Ronald G Crystal, Professor and Chairman of the Department of Genetic Medicine, Weill Cornell Medical College, spoke to Drug Target Review’s Victoria Rees about his research into Alzheimer’s disease and why gene therapies represent a promising area of research for neurodegenerative conditions.

news

Intranasal COVID-19 vaccine shown to be effective in animal models

26 August 2021 | By Anna Begley (Drug Target Review)

A nasal spray of the COVID-19 Vaccine Oxford/AstraZeneca was found to protect hamsters and monkeys against SARS-CoV-2 in an NIH study.

news

CureVac and GSK COVID-19 vaccine shows promise in pre-clinical study

17 August 2021 | By Anna Begley (Drug Target Review)

CureVac and GSK's second-generation mRNA COVID-19 vaccine candidate, CV2CoV, demonstrated improved immune response in a pre-clinical study.

article

Exclusive report: AI & Informatics: Drug discovery and development

11 August 2021 | By Drug Target Review

In this original report, find an in-depth analysis of AI and informatics within imaging, synthetic biology, drug screening and drug design. Featured interviews with experts from AstraZeneca, Auransa, PolarisQB and Chalmers University of Technology.

news

Triple drug combination shows promise for pancreatic cancer treatment

10 August 2021 | By Anna Begley (Drug Target Review)

MIT researchers have shown that a combination of three drugs can eliminate pancreatic tumours in mice, possibly leading to new therapies.

news

Licensed drug may reduce COVID-19 infection by 70 percent

6 August 2021 | By Anna Begley (Drug Target Review)

Fenofibrate and its active form, fenofibric acid, have been shown to significantly reduce COVID-19 infection in human cells.

news

Novel database could accelerate drug repurposing for various diseases

4 August 2021 | By Anna Begley (Drug Target Review)

NICEdrug.ch is an open-access database that may help scientists assess potential drugs for a range of diseases more quickly.

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Pharmacology