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Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer.
Scientists from LifeArc, an independent medical research charity in the UK, explain how they’re using the latest imaging technologies to progress drug discovery campaigns and identify the most promising candidates for antibody-based therapies.
This in-depth focus looks at the modification of stem cells to facilitate their efficient delivery to tumours, highlighting the new development of pluripotent stem cells.
In this issue: novel approaches to produce radiolabelled antibodies, the use of CRISPR/Cas9 to accelerate the development of targeted therapies and utilisation of stem cells to study the effects of cannabis on neuronal development.
Researchers from the University of Zurich have created a new method for radiolabelling antibodies using UV light - with proteins being ready-to-use for cancer imaging or therapy in less than 15 minutes.
Researchers have finally shown how inflammation caused by H. pylori infection causes the proliferation of gastric epithelial stem cells, leading to gastric tumours.
Method IDs which target therapies, inadequately on their own, can be paired up to kill non-responsive cancers...
Researchers used CRISPR technology to disrupt every gene in over 300 cancer models from 30 cancer types and discover thousands of key genes essential for cancer's survival...
Researchers have used single-cell sequencing to map the landscape of myeloid cells in tumours from patients with lung cancer...
Vaccination with as few as four tumour antigens generated antigen-specific responses, reduced intestinal tumours, and improved survival in a mouse model of Lynch syndrome...
A combination of chemotherapy and chimeric antigen receptor (CAR) T cells designed to target the protein HER2 was found to be safe and showed clinical responses in paediatric and adult patients with advanced HER2-positive sarcoma...
Mitochondria are found to be associated with the effectiveness of oncological drug therapies...
Researchers have found that the enzyme USP15 could potentially lead to new therapies for both breast and pancreatic cancer...
A method of imaging using longer wavelengths could mean that tiny tumours and clusters of cancer cells may be detected earlier than current methods allow...
A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...
Genomics could be used to match drugs to patients better, with these genetic signatures also giving an earlier insight into detection of the condition...
