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Nanobody cocktail shown to block SARS-CoV-2 infection in mouse models
Researchers have used cryo-EM to show that a new nanobody cocktail can bind to the S protein of SARS-CoV-2, neutralising the coronavirus.
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Molecular Targets
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Inhibiting METTL3 enzyme combats acute myeloid leukaemia in mice
Scientists have developed a drug called STM2457 which inhibits a key enzyme involved in acute myeloid leukaemia.
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Role of macrophages in blood flow regulation after tissue damage revealed
Researchers have shown in mice that macrophages play a role in controlling blood flow and healing following tissue damage.
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Molecule in body that blocks antibody binding to SARS-CoV-2 discovered
Biliverdin attaches to a region of the SARS-CoV-2 Spike protein, stabilising it so that it is not able to expose its structure to antibodies, a new study has shown.
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Experimental drug shown to reverse effects of Alzheimer’s in mice
Oral doses of a new drug named CA administered to mouse models led to improvements in Alzheimer's disease, including memory.
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Compound that targets BRAT1 protein could be used to kill cancer cells
Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.
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Structure of PLEKHA7 protein domain imaged, presenting cancer drug target
A range of imaging and computational techniques were used by researchers to discover the structure of the PH domain of PLEKHA7.
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Targeting TNF to treat Dupuytren’s disease, frozen shoulder and POCD
Dr James Woody discusses off-patent indications for anti-TNF to address unmet patient needs in pain, inflammation and beyond.
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Brain organoids reveal mechanisms of virus-induced microcephaly
Researchers have shown how different viruses such as HSV-1 and Zika can lead to microcephaly using brain organoids.
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Exploring the connection between COVID-19 and diabetes
Dr Brittany Busse discusses why COVID-19 can influence the onset of diabetes and how this could shape the development of therapeutics.
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Reduced levels of H2S in rat brains protects against dementia
A study has shown that treatments to reduce levels of hydrogen sulphide (H2S) in the brain may help to prevent dementia.
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Self-assembling nanofibres could prevent damage from inflammation
A team has demonstrated in mouse models that a self-assembling nanofibre material could limit the damage caused by cytokines in inflammatory diseases.
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Team identifies potential drug to repurpose against melanoma
Researchers say that inhibiting NLRP3 with Dapansutrile could be an effective strategy to prevent melanoma tumour growth.
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Researchers discover strategy to reverse poor stress response in mice
Studying the mouse gene Ophn1, researchers have found its removal causes stressed behaviours, also identifying three ways to reverse this effect.
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Dynamic model of SARS-CoV-2 S protein reveals vaccine targets
A model of the SARS-CoV-2 Spike protein surface has uncovered vulnerabilities that researchers say could inform the development of COVID-19 vaccines.
