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UTX gene mutation “robs” individuals of natural cancer protection
The UTX gene mutation was found to lead to an increased cancer risk, presenting a potential drug target for preventative therapies.
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Molecular Targets
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Scientists explore CA2 neuron mitochondria for memory loss targets
The team will receive $2 million over five years to investigate the CA2 brain region for the development of neurological therapies.
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MicroRNA in red blood cells causes vascular damage in type 2 diabetes
Researchers discovered that cardiovascular damage was caused by reduced microRNA-210 levels in patient cells and mice with type 2 diabetes.
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IL-36Ra discovery may help heal skin wounds from ischemia reperfusion
The absence of interleukin-36 receptor antagonist (IL-36Ra) significantly slowed down wound healing in ischemia-reperfusion injuries in mice.
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Researchers identify RNA molecule that suppresses prostate tumours
Scientists discover a long noncoding RNA, termed NXTAR, and a small molecule drug that could be used to treat prostate cancer.
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Fruit flies could unveil new genetic targets for obesity treatment
Researchers used obese fruit flies to analyse how gene activities affect triacylglyceride levels, unveiling novel drug targets for obesity.
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Researchers identify COVID-19 proteins that cause blood vessel damage
Scientists revealed five proteins that cause blood vessel damage in COVID-19 patients, potentially leading to new drug targets.
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Pathway and enzyme responsible for CKD thrombosis identified
Scientists have discovered a novel pathway and enzyme that causes thrombosis in chronic kidney disease (CKD) patients, indicating a new drug target.
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GLP-1 and GIP receptor agonists reduce mouse obesity in pre-clinical study
Treatment with Viking Therapeutics' dual agonists resulted in mean reductions in body weight of up to 27 percent compared to semaglutide-treated animals.
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Scientists target ALS and dementia RNA using novel molecule
The small molecule successfully targeted the C9orf72 gene that causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
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Engineering better CAR T cells with Professor Ann Ager, Cardiff University
Watch this exclusive interview with Professor Ann Ager, Cardiff University, to discover how CAR T cells could be targeted against solid tumours.
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Groundbreaking data tool may uncover novel class of GPCRs
A new computer-aided tool maps allosteric sites in G protein-coupled receptors to search for allosteric drugs to treat a range of diseases.
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Experimental mouse model reveals potential progeria treatment strategy
Scientists have found that Hutchinson-Gilford Progeria Syndrome (HGPS) can be prevented with treatments targeting the cardiovascular system using a novel mouse model.
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Specific mechanism found to control transition from acute to chronic pain
A new study is the first to identify N-acylethanolamine acid amidase as a new drug target to treat different forms of chronic pain.
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Molecular targets for breast cancer relapse identified in new study
German, Norwegian and British scientists have identified molecular targets for therapies that could prevent breast cancer recurrence.
