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Atomic force microscopy reveals structure of ribosome stalk proteins
Researchers have used force atomic microscopy to show the structural dynamics at ribosome stalk proteins when building new proteins.
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Blood vessel damage likely causes neurological symptoms of COVID-19, finds study
A new study suggests that inflammation and blood vessel damage may be the primary causes of neurological symptoms in COVID-19 patients, instead of the virus infecting the brain.
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Microscopy reveals four classes of SARS-CoV-2 neutralising antibodies
Researchers show that neutralising antibodies targeting the SARS-CoV-2 Spike protein have four distinct structures.
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Researchers discover how SARS-CoV-2 reaches the brain
A new study has identified the mechanisms through which the SARS-CoV-2 virus enters the brain and how the immune system responds once it does.
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Product hub: Vi-CELL BLU cell viability/counting analyser
The Vi-CELL BLU automates the widely accepted trypan blue dye exclusion method for cell viability that has historically been performed with a light microscope, pipette, and a hemacytometer.
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Novel imaging technique captures multiple tissues in 3D
A new imaging method called FLASH can provide a visualisation of several tissue types in a 3D format, its developers say.
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The latest pre-clinical HIV vaccine developments
This article lists three of the most recent advances in pre-clinical HIV research and vaccine development.
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New insight to guide discovery of drugs targeting ion channels
The study shows how drug-like small molecules inhibit the activity of Transient Receptor Potential Canonical 1/4/5 (TRPC1/4/5) channels and could transform the development of future therapies.
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3D view of SARS-CoV-2 replication cycle could enable antiviral drug development
Scientists have shown how SARS-CoV-2 induces changes in the architecture of host cells to drive replication and made their data available to all.
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Scalable method to image protein levels and changes developed
Using a new CRISPR-Cas9 tagging strategy, researchers have developed a method that enables the imaging of hundreds of proteins in parallel.
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Acquiring structural data on membrane proteins – a spotlight on GPCRs
Lan Zhu from Arizona State University explains how cryo-EM methods can be used to obtain structural information on membrane proteins such as GPCRs.
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ebook: Phenotypic screening with iPSC-derived cardiomyocytes and neurons
Identify therapeutic effects and adverse responses to compounds earlier in the drug discovery process.
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New imaging method reveals glycan vaccine targets on HIV molecules
Using cryo-electron microscopy and site-specific mass spectrometry, researchers have mapped the glycans that shield HIV from the immune system.
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ebook: Eliminate 50/60 Hz line-frequency noise in less than one second
A major challenge within electrophysiology labs is 50 or 60 Hz line frequency electrical noise, which can either distort or completely drown out biological signal.
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Webinar: High-content analysis and phenotypic characterisation of 2D and 3D cellular models
Combining 2D and 3D models with live-cell assays allows monitoring of cell responses in real time and provides important insights about compound treatment effects, biological complexity, and physiological relevance of assay results.
