Mass Spectrometry

LiP-mass spectrometric analysis measures molecular interactions

2 February 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have systematically analysed and quantified the interactions of all proteins with metabolites on the level of the whole proteome...

GalNAc-T6 enzyme selectively up-regulated in colon adenocarcinomas

29 January 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified an enzyme that appears to drive the conversion of normal colon tissue into cancer...

Charles River announces success of integrated discovery project with ENYO Pharma

29 November 2017 | By Charles River Laboratories

Capture compound mass spectrometry technology enables target identification...

Richard Goodwin joins DTR Advisory Board

11 October 2017 | By Steve Bremer (Drug Target Review)

Dr Goodwin is the latest top-level scientist to join DTR's advisory board

Mass spectrometry imaging in drug discovery

11 September 2017 | By Josephine Bunch (Lead Scientist: NPL), Richard JA Goodwin (Principal Scientist - Drug Safety and Metabolism at AstraZeneca)

Mass spectrometry imaging allows direct measurement of the molecular composition of a sample. It can be used to image the spatial distribution of exogenous drugs and endogenous metabolites simultaneously over the surface of tissue sections or small biopsy, allowing new insights into both compound efficacy and safety during drug discovery.

Imaging In-Depth Focus 2017

11 September 2017 | By Drug Target Review

This In-Depth Focus explores current uses and future development in mass spectrometry imaging for bringing new drugs to market...

Drug Target Review – Issue #3 2017

6 September 2017 | By Drug Target Review

Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...

UC biologist looks at butterflies to help solve human infertility

28 June 2017 | By Niamh Marriott (Drug Target Review)

UC biologist helps decode the structural complexities of male butterfly ejaculate and co-evolving female reproductive tract. Findings from these biochemical relationships may help unlock certain mysteries of human infertility

Using native mass spectrometry to inform drug discovery

2 June 2017 | By Carol V Robinson, Hsin-Yung Yen, Idlir Liko, Jonathan ST Hopper, Timothy Allison

Mass spectrometry (MS) performed under native-like conditions (nMS) is a promising approach for studying protein-drug interactions, and has already informed treatments of some of the most intractable diseases including cancer, diabetes and Alzheimer’s.

Drug Target Review – Issue #2 2017

2 June 2017 | By Drug Target Review

Included in this issue: Technology convergence improves testing; Screening; Stem Cells; Targets; Mass Spectrometry; and Therapeutics in Alzheimer's disease...

Metabolic markers accurately diagnose typhoid fever

9 May 2017 | By Niamh Marriott (Drug Target Review)

Researchers have identified a metabolite 'signature' that can accurately distinguish typhoid from other fever-inducing tropical diseases using patient blood samples.

New method for early screening of colorectal cancer

26 April 2017 | By Niamh Marriott (Drug Target Review)

A highly sensitive method that can detect even the earlier stages of colorectal cancer has been developed by researchers in Japan.

Creating the ‘google earth’ of tumours

20 April 2017 | By Josephine Bunch (Lead Scientist: NPL)

We caught up with Dr Josephine Bunch to find out how NPL are using the Cancer Research Grand Challenge funding & novel imaging techniques to map cancer tumours...

EU funds research on biofuels and infectious diseases

18 April 2017 | By Niamh Marriott (Drug Target Review)

Biochemist and physician Professor Ivan Dikic and microbiologist Professor Volker Müller are very honoured that their pioneering research projects have been selected for this substantial financial support.

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