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New study may improve enzyme replacement therapy for Pompe patients
Researchers have developed a new method that could make enzyme replacement therapy more efficient for Pompe disease treatment.
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Ligands
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New insight to guide discovery of drugs targeting ion channels
The study shows how drug-like small molecules inhibit the activity of Transient Receptor Potential Canonical 1/4/5 (TRPC1/4/5) channels and could transform the development of future therapies.
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Mystery glycoprotein could prevent respiratory distress
According to researchers, the DMBT1S8 molecule can halt inflammation in the respiratory tract through its interaction with the Siglec-8 receptor on immune cells.
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Machine learning reveals potential COVID-19 therapeutic compounds
A drug screen using machine learning has identified hundreds of potential drugs that could be used to treat COVID-19, researchers say.
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Empty phage viruses as a method to combat influenza
A group of German researchers has proposed an empty phage capsid with ligands on its surface as a novel technique to treat influenza.
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Novel ligands developed with high affinity for Alzheimer’s receptors
A group of researchers has synthesised a new class of ligands which bind with high affinity to imidazoline I2 receptors, a drug target for Alzheimer's disease.
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Artificial binding protein could be developed into a novel anti-viral or cancer therapy
Scientists have created an artificial protein able to recognise and bind cell surface carbohydrates with high affinity and selectivity.
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Novel molecules to adjust the circadian rhythm
A collaborative team of researchers has discovered two molecules that target the melatonin receptor, responsible for regulating the circadian rhythm. This article delves into their study and its therapeutic relevance for the body clock.
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Mutated blood stem cell receptors could be therapeutic targets for leukaemia
Researchers have identified that in leukaemia, mutated receptors allow blood stem cells to activate one another without the proper signal and suggest this discovery could lead to targeted novel therapies.
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Method to make integrin receptor-targeting drugs safer in future presented in study
Research into the structure of the drug-integrin complex has enabled the creation of drugs which inhibit integrin as effectively as currently used compounds, without causing excessive bleeding.
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Protein decoy hinders progress of lung cancer growth in mice
Researchers have slowed the spread of a type of non-small cell lung cancer in mice by neutralising a protein that would otherwise cause tumour growth.
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Researchers identify novel signalling systems in cells
A study has revealed five new signalling processes in GPCR receptors on cells that have high therapeutic potential.
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Method developed for quicker and simpler production of lipidated proteins
A simple and direct method of introducing lipids into protein has been developed using palladium as a catalyst.
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New strategy developed to speed up drug discovery process
A new drug discovery strategy predicts the clinical actions of new compounds to promote desired clinical responses and avoid side effects.
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Application note: Faster and more reliable quantification of oligonucleotide interaction with human serum albumin using MST
Antisense oligonucleotides are an emerging therapeutic option for treating diseases with known genetic origin.
