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Method to make cell cultures act more like normal cells discovered
Scientists have shown that culturing cells with a modified serum could allow drugs to be screened for toxicity earlier during research.
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In Vitro
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New single-cell transcriptomics method does not put cells under stress
Researchers have created a new single-cell transcriptomics approach that cryopreserves cells, limiting the stress they are put under.
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How RNA therapeutics can be used to treat retinitis pigmentosa
Sahm Nasseri discusses promising pre-clinical results of an RNA-based therapeutic developed to treat retinitis pigmentosa type 11.
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New in vitro assay developed to test potential NASH drugs
An assay that combines 3D disease models and automated AI-based fibrosis quantification could accelerate NASH drug discovery.
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Developing a broadly neutralising antibody therapeutic to combat SARS-CoV-2
With the ongoing COVID-19 pandemic, new treatments continue to be urgently needed. One potential solution is antibody therapeutics, which can be used to neutralise the coronavirus and provide future immunity to patients. Here, Dr Laura Walker from Adagio Therapeutics discusses how antibodies can be used in the fight against Severe…
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Product hub: A cost, time and labour-saving protein purification platform
In February 2021, US biotech company GenScript launched an updated version of its semi-automated system, AmMag™ SA Plus.
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Hydrogel used to revert cancer cells back to cancer stem cells
A new hydrogel has been shown to convert cancer cells to cancer stem cells within 24 hours, in six different human cancer cell line types.
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Three common antiviral drugs effective against SARS-CoV-2 in vitro
A team has shown that tilorone, quinacrine and pyronaridine are effective at inhibiting the replication of SARS-CoV-2 in vitro.
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Organ-on-a-chip model developed to aid sickle cell disease treatment
Researchers have developed a novel organ-on-a-chip model of sickle cell disease to improve personalised medicine.
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Researchers develop model of early human embryo from skin cells
Scientists have created the first model of early human embryos by reprogramming fibroblasts into a blastocyst-like structures.
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High-CBD cannabis extracts could provide COVID-19 treatment
Cannabidiol's (CBD) anti-inflammatory properties could be harnessed to treat or prevent COVID-19, according to a new study.
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New inhibitor found to combat drug-resistant cancer cells
A team has developed a novel inhibitor that blocks a protein in cancer cells, making drug-resistant tumours respond to chemotherapy.
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Researchers identify antibodies with potent effects against malaria
Six antibodies specific to the circumsporozoite protein of the malaria parasite have shown promise as therapeutic interventions, a study has shown.
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NOX5: a novel target for sensitising melanoma to therapies
Vito Quaranta, professor of biochemistry and pharmacology, discusses how cancerous cells adopting novel mechanisms of energy production could be sensitised to existing therapies with a focus on melanoma.
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Team modifies therapeutic molecule to improve stroke treatment
Researchers have shown that adding a polymer to glutamate-oxaloacetate transaminase means the molecule can treat stroke for up to six days in rats.
