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Immunology

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New model can help translate mice research into human health results

5 August 2019 | By Rachael Harper (Drug Target Review)

A new mouse model, called 'wildlings', has been developed which better mirrors human immune responses than standard laboratory mice.

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Whitepaper: IHC/ICC Protocol Guide

22 July 2019 | By Bio-Techne

Immunohistochemistry (IHC) and immunocytochemistry (ICC) are techniques employed to localize antigen expression and are dependent on specific epitope-antibody interactions.

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Whitepaper: CD4+ T-Cell Subsets

22 July 2019 | By Bio-Techne

CD4+ T-cells play a central role in directing adaptive immune responses against invading microbial pathogens.

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Whitepaper: Immune Cell Isolation & Culture

22 July 2019 | By Bio-Techne

Immune cell isolation and culture are necessary for both basic research aimed at investigating the functions of different immune cell types, and for expanding specific immune cell populations for therapeutic purposes.

news

Macrophages identified as cause of endometriotic pain

12 July 2019 | By Fraser Owen (Drug Target Review)

Researchers have discovered that macrophages are a key cause for pain in women with endometriosis so could be a treatment target for the condition.

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Gene activity app could reduce live model usage

1 July 2019 | By Victoria Rees (Drug Target Review)

Researchers have developed an app which displays the effects of diseases in mice models and can be accessed globally.

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Study suggests immune cells play vital role in fungal disease

1 July 2019 | By Victoria Rees (Drug Target Review)

New research has revealed the immune cells may be critical in moving pathogenic fungal spores to the central nervous system, pointing to drug target.

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Job cuts limit cardiovascular and diabetes research and development

25 June 2019 | By Drug Target Review

Pharmaceutical company, Sanofi, will eliminate jobs in France and Germany and end new in-house cardiology research programmes.

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Immune cells could be key to tuberculosis treatment, study finds

7 June 2019 | By Victoria Rees (Drug Target Review)

Researchers have found that certain immune cells aid in fighting tuberculosis bacteria, providing a new drug target.

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Creating blood vessels on demand

4 April 2019 | By Drug Target Review

A new study shows that stable angiogenesis can be achieved by simply injecting a hydrogel with mechanical properties resembling that of a blood clot...

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FGL2 protein may be an effective target for GBM

28 January 2019 | By Drug Target Review

Researchers have discovered an immune regulator that appears to dictate glioblastoma progression by shutting down immune surveillance...

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Stopping inflammation using a molecular switch

15 January 2019 | By Iqra Farooq (Drug Target Review)

A component in the ubiquitin system has been described as being able to deactivate the innante immune system and could help to prevent immune conditions...

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Engineered T-cells promote acceptance of organs after transplant

15 January 2019 | By Iqra Farooq (Drug Target Review)

Controlling coronin 1 in T-cells could lead to the immune system not attacking transplanted organs, but still fighting other infections...

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Oral squamous cell carcinoma prognostic signature identified

6 December 2018 | By Drug Target Review

Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis...

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T-cells engineered to recognise tumours expressing the CD30 protein marker

4 December 2018 | By Drug Target Review

Researchers have genetically engineered immune cells to recognise and fight Hodgkin and non-Hodgkin lymphoma cells...

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Immunology