High Throughput Screening (HTS)

Profiling the genome hundreds of variations at a time

24 May 2018 | By Drug Target Review

A CRISPR-Cas9 high-throughput strategy creates the possibility to rapidly profile and identify genes and DNA sequence variations key to different traits and diseases.

High-throughput screening capable assays in 3D

1 May 2018 | By Horst Flotow, Jane Spencer-Fry

High-throughput screening (HTS) has become an integral part of early stage drug discovery. This article looks at the use of the latest in vitro 3D cell and tissue culture model systems in HTS. We also highlight some of the bottlenecks and attempt a look into our crystal ball to identify…

Application note: Simultaneous dual phosphoprotein target analysis with Alpha Terbium SureFire Ultra Multiplex

20 March 2018 | By Andrea Brown (TGR BioSciences), Antony Sheehan (TGR BioSciences), Michael Crouch (TGR BioSciences), Vincent Dupriez (PerkinElmer)

This application note discusses how the Alpha SureFire® Ultra™ Multiplex technology provides a phosphoprotein multiplexing detection platform that is truly homogeneous and high throughput.

Under the microscope: Choosing the best microplate reader

19 March 2018 | By Mark Wigglesworth (Director High-Throughput Screening - AstraZeneca)

Efficient microplate readers play an important role in effective hit molecule discovery. Mark Wigglesworth, of AstraZeneca, explains what he looks for in this technology.

High throughput flow cytometry for multifactorial evaluation of novel therapeutic candidates using an innovative in vitro immunooncology screening platform

19 March 2018 | By IntelliCyt Corporation

This recent webinar focused on the role of IntelliCyt’s iQue Screener PLUS platform as a high throughput suspension cell screening platform to facilitate simultaneous assessment of multiple parameters, while using minimal sample volumes.

Lab Automation In-Depth Focus 2018

16 March 2018 | By Drug Target Review

In this issue: how lab automation has accelerated pharmaceutical research by simplifying operations, reducing manual tasks and increasing the efficiency, quality and reproducibility of results.

Assays In-Depth Focus 2018

14 March 2018 | By Drug Target Review

In this In-Depth Focus: high throughput strategies for antibody library screening, and the latest in vitro 3D cell and tissue culture model systems in HTS.

GAPSA reveals new HIV targets

28 February 2018 | By Drug Target Review

Researchers have developed the first-ever high-throughput, genome-scale imaging-based approach to investigate protein stability...

Charles River Laboratories makes investments in high-throughput screening infrastructure

5 February 2018 | By Charles River Laboratories

Signs collaboration agreement with AstraZeneca to offer state-of-the-art technology to clients.

BMG LABTECH Australia celebrates 20 years of customer service excellence in the APAC region

16 January 2018 | By BMG Labtech GmbH

This year, BMG LABTECH’s Australian office celebrates 20 years of innovation and steady growth. The office was established in January 1998 to support Australia and the APAC region, offering excellent sales and customer service for BMG LABTECH’s wide range of dedicated and multi-mode microplate readers.

High throughput flow cytometry for multifactorial evaluation of novel therapeutic candidates using an innovative In vitro immuno-oncology screening platform

4 January 2018 | By IntelliCyt Corporation

In this webinar, speakers discussed how the IntelliCyt iQue Screener Plus platform is being utilised to deliver rich datasets for compound screening, target validation and is how it is transforming immuno-oncology.

Application note: High throughput quantitation of cytokine biomarkers using LANCE Ultra TR-FRET assays

4 January 2018 | By Jen Carlstrom (PerkinElmer), Roger Bosse (PerkinElmer), Stephen Hurt (PerkinElmer)

In this application note, PerkinElmer demonstrates the sensitivity, robust performance, and HTS suitability of the LANCE Ultra cytokine biomarker kits.

Application note: Development and utilisation of bromodomain and extra terminal domain (BET) assays using AlphaLISA technology

3 January 2018 | By Daniel Cardillo (PerkinElmer), Dawn Nida (PerkinElmer), Hong Cao (PerkinElmer), Jen Carlstrom (PerkinElmer)

In this application note, PerkinElmer demonstrates the ease and utility of using AlphaLISA®, a homogeneous assay format, to screen for small molecular inhibitors of BET bromodomains.

BMG Labtech GmbH

Expert view: Optimising the hit-to-lead workflow

13 December 2017 | By Dr. Paul Wylie (Head of Applications at TTP Labtech)

Hits identified in high-throughput screens are evaluated within the hit-to-lead phase of drug discovery, where they undergo an iterative optimisation process employing a variety of techniques to identify promising lead compounds to move forward to the lead optimisation phase.