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Researchers use new CRISPR method to alter specific bacteria strains
A study has demonstrated how to use CRISPR to deliver DNA to particular bacteria, which could be used as an alternative to antibiotics.
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Gene Therapy
Gene Therapy is the introduction of normal genes into cells in place of missing or defective ones in order to correct genetic disorders.
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Researchers find DNA therapy could treat patients with DMD
A study has revealed that using DNA-like molecules to repair gene mutations in models could act as a successful therapy for patients.
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CRISPR used to treat Duchenne muscular dystrophy in mice
A study has shown that CRISPR can be used as a regenerative technique to treat Duchenne muscular dystrophy, which could be developed as a therapeutic option for humans.
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Genomic medicine: cracking genomes to cure ‘incurable’ diseases
We are on the precipice of realising the true potential of genomics studies. Following completion of the Human Genome Project six years ago, huge strides have been made in understanding how the genome works, shedding light on disease pathogenesis and forging therapeutic efforts. In this article, Pushpanathan Muthuirulan explains how…
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New gene therapy repairs neuron stroke damage in mice
Researchers have developed a new treatment method which turned glial cells into functioning neurons in mice after stroke.
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Genomics In-Depth Focus 2019
In this In-Depth Focus are articles on how genomics could revolutionise clinical treatment and an insight into the promise and pitfalls of using CRISPR.
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Drug Target Review – Issue 3 2019
This issue includes an investigation into utilising recombinant antibodies for research, a highlight on protein design using computational methods and an examination of the advances in genomic medicine. Also in the issue are articles on next generation sequencing and upstream bioprocessing.
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Tuberculosis mutation discovery could lead to better treatments
New gene mutation discovery could lead to more rapid and effective therapies for tuberculosis.
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Researchers reverse obesity in mice using CRISPR-Cas9
A study has used CRISPR-Cas9 to treat obesity and type 2 diabetes symptoms in mice, highlighting the potential use in humans.
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Novel bacteria gene activation method developed
Researchers have created a new technique for activating genes using bacteria which could have therapeutic uses.
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‘Ubiquitin clipping’ proteomics technique could be used as novel treatment
A new technique called ‘ubiquitin clipping’ has been created which could aid proteomics research and the development of new drugs for ubiquitination.
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Targeting a blood stem cell subset shows lasting gene editing
Scientists report how editing a portion of stem cells with CRISPR-Cas9 is sufficient for long-term reactivation of therapeutic haemoglobin.
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New molecule developed to fight microRNA-related disease
Newly developed HDO-antimiR could lead to new ways to treat diseases which are caused by malfunctioning miRNAs.
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No-cut CRISPR could be used to treat muscular dystrophy
Researchers have successfully used a no-cut CRISPR gene editing technique as a therapy for muscular dystrophy in mice models.
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New system enables improved pre-clinical testing of heart drugs
Researchers have extended the life of heart segments from 24 hours to six days, enabling pre-clinical trials to experiment on these new models for longer periods of time.
