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World’s first artificial enzymes created using synthetic biology
2 December 2014 | By The Medical Research Council
Medical Research Council scientists have created the world’s first enzymes made from artificial genetic material...
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Enzymes
Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyse, chemical reactions.
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Synthetic macrocyclic receptors as tools in drug delivery and drug discovery
Macrocyclic compounds (see Figure 1) have fascinated medicinal chemists for generations. The first ones which have been characterised are the naturally occurring cyclodextrins (CDs), cyclic oligomers of glucose, which can be obtained by bacterial synthesis from starch. Calixarenes (CXs) were among the first man-made macrocycles, followed by crown ethers (Pedersen,…
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Daiichi Sankyo to acquire Ambit Biosciences
30 September 2014 | By Daiichi Sankyo
Lead compound, Quizartinib, will further build Daiichi Sankyo oncology pipeline...
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Boehringer Ingelheim’s volasertib showed in a Phase II study an improvement in overall survival in older AML patients
9 July 2014 | By Boehringer Ingelheim
Results from a Phase II study, published in the American Society of Hematology journal Blood, showed patients with previously untreated acute myeloid leukemia aged 65 or older and ineligible for intensive remission induction therapy, lived longer...
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Targeting the ubiquitin-proteasome system
The ubiquitin-proteasome system (UPS) is a hierarchical enzymatic cascade that plays an essential role in a broad range of cellular pathways and is found in cytoplasmic and nuclear actions of all eukaryotic cells...
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Collaborative drug discovery: an update on the progress of such initiatives
Despite the ever increasing efforts being expended for drug discovery purposes, the number of approved drugs remains relatively static. A variety of explanations have been provided to explain this observation and initiatives to remedy this situation have been implemented. Many of these initiatives are still works-in-progress and whether these will…
