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Researchers identify new arthritis severity gene
A new gene associated with disease severity in models of rheumatoid arthritis has been identified by...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Promising drug targets for t-cell lymphoblastic leukaemia
Silencing the gene behind the production of HSP90, a target in the HSF1 pathway, effectively kills leukaemia cells, without affecting healthy cells...
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Curcumin eye drops may treat glaucoma
A derivative of turmeric could be used in eye drops to treat the early stages of glaucoma...
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Derm-BOT compound relieves chronic pain
A modified form of botulinum toxin gives long-lasting pain relief in mice without adverse effects...
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Bacterial outer membranes may be key to new antibiotics
The outer membrane surrounding the cell wall of bacteria may be a key target for approaches to a new form of antibacterial drugs...
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Cancer drug screening: the historical perspective
Chemotherapy with cytotoxic and growth inhibitory drugs have played an important role in cancer therapy, used either alone or in combination with other treatment modalities such as surgery, radiation or biological therapy. Chemotherapy, in most instances, was the only alternative treatment for metastatic cancer – mainly given as drug combinations...
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Revolutionary eye drops to treat age-related macular degeneration
Scientists are one step closer to developing an eye drop that could revolutionise treatment for age-related macular degeneration (AMD)...
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MicroRNA: a new target for breast cancer research?
A study has identified microRNA as a possible candidate to be used as a drug target for breast cancer research...
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IgE protein may protect against skin cancer
The components of the immune system that trigger allergic reactions may also help protect the skin against cancer, suggest new findings...
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Hunger hormones offer promising avenue for addiction treatment
Hormones that signal the body's state of hunger and fullness could be the key to new treatments for drug and alcohol addiction...
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Study pinpoints the ‘Big Bang’ of tau-induced Alzheimer’s neurodegeneration
Scientists in the U.S. have identified what they believe to be the genesis of Alzheimer's disease – the precise point at which a healthy tau protein becomes toxic but has not yet formed deadly tangles in the brain. The finding opens up numerous avenues for treatment research.
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New targets found to reduce blood vessel damage in diabetes
Researchers identify new treatment targets for diseases associated with endothelial cell senescence, or ageing, such as diabetes, cardiovascular disease and age-related disorders...
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Next-generation therapeutic helps immune cells detect, destroy cancer
Researchers have found that cancer cells evade destruction by macrophages in two ways...
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Progress toward improved Wilson’s disease drug
Researchers have conducted promising preclinical experiments on a compound that could be used to treat Wilson's disease...
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Experimental drug combined with radiation extends the survival of GBM
A new study has shown that an experimental drug known as AZ32 significantly extends the survival of glioblastoma multiforme, the most common and deadly form of brain cancer...
