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DNA anticancer vaccine targets tumour neoantigens
A DNA vaccine developed through the use of unique tumour antigens could lead the way towards vaccinating people against cancer...
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Catching lung cancer early using molecular profiling
Researchers have identified how they can differentiate between lesions in the airways that are benign and those that could become cancerous...
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Gene responsible for prostate cancer spread identified
Identified using a computer algorithm, the NSD2 gene may be responsible for advancing the spread of prostate cancer, and so could be used as a drug target...
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‘Hidden pocket’ could be targeted to treat strokes
Researchers have identified a tiny hidden pocket on the NMDA receptor that could be targeted to treat strokes and seizures...
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How gut bacteria affect the treatment of Parkinson’s disease
Researchers have investigated the ability of gut microbiota to influence the bioavailability of levodopa, a drug used in the treatment of Parkinson's...
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ADM-RAMP2 system could be therapeutic target for retinal vein occlusion
Researchers suggest that the retinoprotectivity of the ADM-RAMP2 system makes it an ideal therapeutic target for central retinal vein occlusion (CRVO)...
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GREB1 gene potential drug target for prostate cancer treatment
Researchers in the US have discovered how a gene involved in regulating hormone receptors, GREB1, may contribute to drug resistance in some prostate cancer patients.
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Potential therapeutic target for ALS revealed
Strathmin2 could be used as a biomarker for amyotrophic lateral sclerosis (ALS), a debilitating condition with no proper diagnostic tests or treatments...
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CRISPR/Cas9 shown to limit impact of certain parasitic diseases
Researchers successfully used CRISPR/Cas9 to limit the impact of schistosomiasis and liver fluke infection...
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Stopping inflammation using a molecular switch
A component in the ubiquitin system has been described as being able to deactivate the innante immune system and could help to prevent immune conditions...
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CRISPR repurposed to develop better antibiotics
Mobile-CRISPRi could be used to guide gene expression, in turn control levels of proteins produced, enabling scientists to identify key antibiotic targets...
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Hidden culprit in heart failure discovered
A study has identified that PI3K alpha could be the culprit of heart failure, as it binds to gelsolin, suppressing it and preventing it from working...
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Drug sponge could minimise effects of cancer therapy
A drug 'sponge' could be the future method of soaking up excess drugs within the body after cancer treatments such as chemotherapy to prevent side effects...
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Insights into controlling gene expression
A study has given insight into gene expression and could enable scientists to determine how certain RNAP inhibitors work within the body...
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The mysterious functions of the PCSK9 protein
Researchers have described the methods used to build a model of the 'druggable' PCSK9 inhibitor and detailed how it works...
