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Drug Targets

A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.

Antibiotic resistant bacteria in biofilm

news

Machine learning models predict antibiotic resistance spread

29 October 2021 | By Anna Begley (Drug Target Review)

Scientists have used several machine learning models to predict bacterial gene exchange, which could reveal novel antibiotic targets.

Red blood cells flowing with too many white blood cells, indicating leukaemia

news

Albert Einstein researcher receives NIC award to study two blood cancers

28 October 2021 | By Anna Begley (Drug Target Review)

Professor Ulrich G Steidl received the National Institute of Cancer's Outstanding Investigator Award to study myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML).

news

Scientists target ALS and dementia RNA using novel molecule

28 October 2021 | By Anna Begley (Drug Target Review)

The small molecule successfully targeted the C9orf72 gene that causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

Computer with many medical symbols on screen

news

Groundbreaking data tool may uncover novel class of GPCRs

27 October 2021 | By Anna Begley (Drug Target Review)

A new computer-aided tool maps allosteric sites in G protein-coupled receptors to search for allosteric drugs to treat a range of diseases.

Mouse on lab tubes with DNA molecule in background

news

Experimental mouse model reveals potential progeria treatment strategy

27 October 2021 | By Anna Begley (Drug Target Review)

Scientists have found that Hutchinson-Gilford Progeria Syndrome (HGPS) can be prevented with treatments targeting the cardiovascular system using a novel mouse model.

news

Specific mechanism found to control transition from acute to chronic pain

27 October 2021 | By Anna Begley (Drug Target Review)

A new study is the first to identify N-acylethanolamine acid amidase as a new drug target to treat different forms of chronic pain.

news

Molecular targets for breast cancer relapse identified in new study

26 October 2021 | By Anna Begley (Drug Target Review)

German, Norwegian and British scientists have identified molecular targets for therapies that could prevent breast cancer recurrence.

Pain relief tablets spilled out on table

article

Peptides: a promising alternative to opioids for chronic pain relief

25 October 2021 | By Anna Begley (Drug Target Review), Anton Simeonov, Victoria Rees (Drug Target Review)

In an exclusive with Drug Target Review, researchers at the University at Buffalo explain how they developed a novel peptide that could be a future treatment for chronic inflammatory pain.

news

MIT study reveals how lipid imbalance affects cancer growth in mice

21 October 2021 | By Anna Begley (Drug Target Review)

In a new study, a calorie-restricted diet significantly reduced tumour growth in mouse models, suggesting new possibilities for cancer therapies.

news

Senescent cell treatment could combat age-related diseases

20 October 2021 | By Anna Begley (Drug Target Review)

Scientists have developed a novel technique for the targeted clearance of senescent cells to improve treatments for ageing and other conditions.

news

Medicenna’s MDNA11 a promising alternative to checkpoint inhibitors

19 October 2021 | By Anna Begley (Drug Target Review)

Medicenna's IL-2 super-agonist, MDNA11, successfully induced antitumour cells in animal models, a pre-clinical study has revealed.

Biofilm of antibiotic resistant bacteria

news

Antibiotic-free hydrogel fights against drug-resistant bacteria

19 October 2021 | By Anna Begley (Drug Target Review)

New dendritic hydrogels were tested against several infectious bacteria and could be used as an an antibiotic-free treatment in the future.

news

Measuring microRNAs in blood may indicate dementia risk

14 October 2021 | By Anna Begley (Drug Target Review)

Researchers identified three microRNAs whose levels were associated with mental performance in cells, mice and humans.

Brain scan with red areas, indicating stroke

news

Neurolysin shown to be potential drug target for ischemic stroke

13 October 2021 | By Anna Begley (Drug Target Review)

Researchers are identifying molecules that interact with neurolysin, a peptidase that helps protect the brain against stroke.

news

Wyss Centre initiates collaboration to improve brain tumour treatment

13 October 2021 | By Anna Begley (Drug Target Review)

The Wyss Centre has announced a collaborative project to improve understanding of the brain cancer glioblastoma and develop new personalised therapies.

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Drug Targets