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Trends in pancreatic cancer literature – findings from Elsevier
In a new report, Elsevier describes how it used text mining to reveal the top trends in pancreatic cancer research – this article outlines the findings.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Biomarker for blood vessel damage found in children with SARS-CoV-2
Elevated levels of a biomarker related to blood vessel damage have been found in all children with SARS-CoV-2 infection.
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Role of gene in metastasis of brain cancer revealed
Researchers have shown how increased YTHDF3 expression correlates with brain cancer metastases, making it a target for the condition.
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Inhibiting cadherin 11 significantly increases survival of mice with pancreatic cancer
Mice treated with a small molecule inhibitor of cadherin 11 (CDH11) had reduced pancreatic cancer growth and increased survival time.
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Novel target for pulmonary fibrosis identified using tissue from COVID-19 patients
Study suggests reducing the expression of the methyl-CpG-binding domain 2 (MBD2) protein on macrophages could be a viable therapeutic strategy for lung fibrosis.
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Oral drug blocks SARS-CoV-2 transmission in ferrets, researchers find
A team has found that their drug Molnupiravir (MK-4482/EIDD-2801) acts as an antiviral against SARS-CoV-2 in pre-clinical studies.
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Microscopy reveals four classes of SARS-CoV-2 neutralising antibodies
Researchers show that neutralising antibodies targeting the SARS-CoV-2 Spike protein have four distinct structures.
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New insulin molecule can self-regulate blood sugar in rats
Researchers have developed a novel insulin molecule that responds to glucose levels in the blood sugar of rats, which they say could help patients with type 1 diabetes.
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A novel CAR T-cell therapy for type 1 diabetes
Researchers show how genetically engineered five-module chimeric antigen receptor (5MCAR) T cells can be directed to destroy T cells causing autoimmune diseases.
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Researchers provide new insights into SARS-CoV-2 lung pathology
The new study shows how SARS-CoV-2 significantly remodels cellular processes in just an hour and identifies potential drug targets and therapeutics for COVID-19.
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Mitochondrial protein revealed as target for cardiovascular disease
According to new research, the protein ALDH4A1 is a possible therapeutic target and diagnostic biomarker for cardiovascular disease.
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Combining deep computational learning and synthetic biology
Dr Diogo Camacho from the Wyss Institute at Harvard discusses new research into using machine learning algorithms to analyse RNA sequences and reveal potential drug targets.
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Drug target to tackle COVID-19 inflammatory processes identified
Researchers have shown that the presence of the inflammasome mediated by NLRP3 is a marker and drug target for COVID-19-related cytokine storms.
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A novel blood-brain barrier model for cerebral malaria research
In this article Maria Bernabeu, Group Leader at EMBL, Barcelona, discusses why it is important to research and develop novel therapeutics for cerebral malaria and how her research group intends to develop a 3D blood-brain barrier model for this purpose.
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Researchers discover how SARS-CoV-2 reaches the brain
A new study has identified the mechanisms through which the SARS-CoV-2 virus enters the brain and how the immune system responds once it does.
