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Unlocking the power of the microbiome in life sciences R&D
Anthony Finbow explains how applying microbiome-based evidence to disease modelling will enable researchers to devise more targeted treatments.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Potential therapeutic target identified for stomach cancer
A team has shown that removing the inflammatory signalling protein TNF in a laboratory model prevented stomach cancers from becoming severe.
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Researchers reveal protein function that could improve chemotherapy
Scientists have found that the RFWD3 protein could play a role in recruiting DNA key repair and signalling factors, impacting chemotherapy.
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Human 3D cell-based systems to research gout: drug discovery for a neglected disease
In this article Andrew Nyborg from Horizon Therapeutics discusses why researchers are taking a second look at gout and how they are modelling the condition, which is unique to humans.
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New treatment approach kills lymphoma while sparing healthy cells in mice
By combining natural killer cells with a new molecule called Sialyl-Lewis X, researchers were able to treat lymphoma in mice.
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Single interaction could explain the disparity in COVID-19 effects
According to researchers, an interaction between host microRNA and SARS-CoV-2 could be responsible for the range of disease severities.
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Novel class of targeted cancer therapies could treat myeloid leukaemias
Cancer researchers have created a new class of drugs to selectively target and destroy myeloid leukaemia cells with TET gene mutations.
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New drug may boost vaccine responses in older adults
Researchers have found that spermidine can ramp up autophagy and boost T-cell function, potentially increasing the protective effects of vaccines in older adults.
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Opaganib shows promise in preventing ARDS-induced thrombosis
Opaganib reduced blood clot length and weight in a pre-clinical model of Acute Respiratory Distress Syndrome (ARDS).
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Researchers develop drug discovery tool for RNA
Scientists have created a drug discovery platform that enables the discovery and optimisation of RNA-targeting compounds.
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Genome-wide association study reveals targets for COVID-19 treatments
The study found five key genetic differences when they compared sequences from severe COVID-19 patients to healthy individuals.
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The Editors’ views: Drug Target Review’s 2020 round-up
The Junior Editors of Drug Target Review, Victoria Rees and Hannah Balfour, discuss some of the most noteworthy news and announcements from this year.
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Studies in mice reveal link between obesity and tumour growth
New research has provided a metabolic atlas for insights into obesity and tumours' ability to hide from the immune system.
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Novel target could treat both SARS-CoV-2 and other coronaviruses
Scientists shows targeting cholesterol or phosphatidylinositol phosphate (PIP) could be a promising strategy to combat multiple coronaviruses.
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Non-hallucinogenic version of ibogaine could treat addiction and depression
A non-hallucinogenic version of the psychedelic drug ibogaine could treat psychiatric disorders, pre-clinical trials have shown.
