news UTX gene mutation “robs” individuals of natural cancer protection 10 November 2021 | By Anna Begley (Drug Target Review) The UTX gene mutation was found to lead to an increased cancer risk, presenting a potential drug target for preventative therapies.
news Scientists explore CA2 neuron mitochondria for memory loss targets 10 November 2021 | By Anna Begley (Drug Target Review) The team will receive $2 million over five years to investigate the CA2 brain region for the development of neurological therapies.
news Novel intestine chip enables effective in vitro study of COVID-19 therapies 10 November 2021 | By Anna Begley (Drug Target Review) The intestine chip was infected with a coronavirus to test a variety of drugs, presenting a new method to investigate COVID-19 treatments.
news MicroRNA in red blood cells causes vascular damage in type 2 diabetes 9 November 2021 | By Anna Begley (Drug Target Review) Researchers discovered that cardiovascular damage was caused by reduced microRNA-210 levels in patient cells and mice with type 2 diabetes.
news Soluble fibrinogen a potential target for neurodegeneration 9 November 2021 | By Anna Begley (Drug Target Review) In a pre-clinical study, fibrinogen increased the death of mouse brain neurons, suggeting fibrin can have similar toxic effects on neurons.
news IL-36Ra discovery may help heal skin wounds from ischemia reperfusion 8 November 2021 | By Anna Begley (Drug Target Review) The absence of interleukin-36 receptor antagonist (IL-36Ra) significantly slowed down wound healing in ischemia-reperfusion injuries in mice.
news Researchers identify RNA molecule that suppresses prostate tumours 8 November 2021 | By Anna Begley (Drug Target Review) Scientists discover a long noncoding RNA, termed NXTAR, and a small molecule drug that could be used to treat prostate cancer.
news Fruit flies could unveil new genetic targets for obesity treatment 5 November 2021 | By Anna Begley (Drug Target Review) Researchers used obese fruit flies to analyse how gene activities affect triacylglyceride levels, unveiling novel drug targets for obesity.
news New class of CAR T cells combat previously “untargetable” cancer drivers 4 November 2021 | By Anna Begley (Drug Target Review) The peptide-centric chimeric antigen receptors killed neuroblastoma cells in mice and could potentially expand the pool of immunotherapeutic targets.
news Experimental drug boosts immunotherapy efficacy for pancreatic cancer 4 November 2021 | By Anna Begley (Drug Target Review) An experimental drug enhanced the benefit of immunotherapy, reducing and in some cases eliminating pancreatic cancer in mice.
news Gene therapy bolsters Parkinson’s drug benefits in pre-clinical study 3 November 2021 | By Anna Begley (Drug Target Review) The gene therapy restored the ability of neurons to convert levodopa to dopamine and may help develop therapies to slow disease progression.
news Researchers identify COVID-19 proteins that cause blood vessel damage 3 November 2021 | By Anna Begley (Drug Target Review) Scientists revealed five proteins that cause blood vessel damage in COVID-19 patients, potentially leading to new drug targets.
news Monoclonal antibodies prevent COVID-19 inflammation in macaques 2 November 2021 | By Anna Begley (Drug Target Review) Neutralising monoclonal antibodies protected aged macaque monkeys from SARS-CoV-2 and reduced inflammation, including in cerebrospinal fluid, a new study has shown.
news Pathway and enzyme responsible for CKD thrombosis identified 2 November 2021 | By Anna Begley (Drug Target Review) Scientists have discovered a novel pathway and enzyme that causes thrombosis in chronic kidney disease (CKD) patients, indicating a new drug target.
news Scientists eliminate key Alzheimer’s feature in animal model 1 November 2021 | By Anna Begley (Drug Target Review) Turning off NHE6 in mice in pre-clinical studies prevented amyloid beta aggregation, a key feature of Alzheimer's disease, pointing to new therapies.
