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Drug repurposing

article

Delivering a therapy to kerb COVID-19

4 June 2020 | By Sheraz Gul (Fraunhofer Institute)

Sheraz Gul explores current research developments to help treat and tackle the spread of COVID-19.

article

Using pharmacologically-established medicines to treat COVID-19

28 May 2020 | By Kartick Samanta (DECIEM Inc)

A new suggestion has highlighted that the available pharmacologically-established existing medicines should be used to combat COVID-19.

COVID-19 particle and RNA strand outlined in blue on a black background

news

Collaboration to identify novel COVID-19 drug targets announced

30 April 2020 | By Hannah Balfour (Drug Target Review)

Bringing together protein science, drug discovery experience and innovative technology, a new collaboration aims to identify novel drug targets for COVID-19.

scientists in personal protective equipment looking at samples labelled COVID-19 under a microscope

news

Fundamental molecular research underpins our ability to combat COVD-19, says article

23 April 2020 | By Hannah Balfour (Drug Target Review)

Ali Shilatifard’s article explains how investment in institutes performing molecular research is essential, as it is the foundation for all attempts to combat COVID-19 and other future pandemics.

tablets, capsules and a laboratory scientist in a white coat on a swirling blue background

news

Screening 10,000 compounds identifies six potential COVID-19 therapeutics

17 April 2020 | By Hannah Balfour (Drug Target Review)

High-throughput screening of thousands of compounds has revealed several candidates, including lead compound ebselen, with the potential for treating COVID-19.

drug capsule repelling coronavirus particles

news

COVID-19 Drug Repurposing Database made open-access by Excelra

15 April 2020 | By Hannah Balfour (Drug Target Review)

The enterprise revealed that it has made its COVID-19 Drug Repurposing Database open-access to aid in the search for an effective therapeutic.

news

Ivermectin shows activity against COVID-19 in cell cultures

6 April 2020 | By Hannah Balfour (Drug Target Review)

A study has demonstrated that the anti-parasitic drug ivermectin may be effective against SARS-CoV-2, the virus which causes COVID-19.

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Decoy ACE2 receptors could be promising COVID-19 infection-preventing drug

3 April 2020 | By Hannah Balfour (Drug Target Review)

Recombinant angiotensin converting enzymes (ACE2) reduced infection and viral growth in cell cultures and organoids by acting as a decoy for SARS-CoV-2.

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AI technology to screen existing drugs for use against COVID-19

2 April 2020 | By Victoria Rees (Drug Target Review)

A collaboration aims to utilise a compound library of 15,000 clinically-ready molecules and screen then against three COVID-19 targets.

face mask, white tablets and syringe of medication

news

Nafamostat inhibits SARS-CoV-2 infection, preventing COVID-19 transmission

31 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers have demonstrated that Nafamostat mesylate (Fusan) can inhibit SARS-CoV-2 Spike protein-initiated membrane fusion at concentrations likely achievable and safe in patients.

news

Novel antiviral compound proposed as COVID-19 therapeutic

30 March 2020 | By Victoria Rees (Drug Target Review)

A molecule called BOLD-100, developed to fight cancer, has been suggested as a therapeutic to combat the COVID-19 coronavirus due to its antiviral properties.

news

Researchers to screen compound library for antiviral drugs to combat COVID-19

23 March 2020 | By Victoria Rees (Drug Target Review)

Scripps Research has announced it will screen over 14,000 compounds to see if any present significant activity against COVID-19, for use in a therapeutic.

petri dishes containing bacterial colonies

news

Metal-containing compounds could lead to new antibacterials

2 March 2020 | By Hannah Balfour (Drug Target Review)

International collaboration has shown that compounds with metals in them show antibacterial activity against MRSA, E. coli and A. baumannii.

close up artist impression of intestine wall with villi

news

Gut organoid helped to define leaky gut and could aid in treatment development

11 February 2020 | By Hannah Balfour (Drug Target Review)

Research has shown that leaky gut, the break down of gut lining junctions, could be targeted to reduce inflammation using metformin using an organoid model.

Antiviral treatments lead to development of a new kind of cancer drug

news

Antiviral treatments lead to development of a new kind of cancer drug

24 January 2020 | By Rachael Harper (Drug Target Review)

Drugs that were being developed to treat enterovirus have also been found to treat certain cancers in mice.

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Drug repurposing