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Drug Development

news

Antisense oligonucleotide with potential to combat COVID-19 developed

11 March 2021 | By Victoria Rees (Drug Target Review)

Scientists have designed a compound named ASO-1 that could help to reduce immune response overactivation in patients with COVID-19.

article

What we know about COVID-19 and the inflammatory response

10 March 2021 | By Sadya Arnett (Scientific Writer)

A year on from discovering COVID-19 we are starting to understand why some people suffer more severely after infection. Sadya Arnett discusses recent research into the interconnection between host inflammation and SARS-CoV-2.

article

Developing bioenergetic nanocatalysts, a novel approach to treat neurodegeneration

8 March 2021 | By Hannah Balfour (Drug Target Review)

Mark Mortenson, CSO of Clene Nanomedicine, discusses the use of proprietary gold nanocrystals as catalysts to prevent the progression of, and act as a treatment for, neurodegenerative disease.

news

Reversible male contraceptive shows promise in pre-clinical studies

4 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have discovered the the compound triptonide is safe, effective and reversible as a male contraceptive in animal models.

webinar

Paradigm Shift in Drug Discovery: Discover Small Molecule Degraders Using E3scan™ Technology Platform

4 March 2021 | By Eurofins Discovery

Book your place for our free webinar and learn about how targeted protein degradation (TPD) utilises small molecules to hijack the cellular degradation machinery through the recruitment of E3 ubiquitin ligases to proteins of interest.

webinar

The discovery and challenges of antibodies targeting GPCRs

26 February 2021 | By Domain Therapeutics

Watch our on-demand webinar which focused on the progress achieved in G protein-coupled receptor (GPCR) therapeutic antibody-based discovery and development.

news

Behavioural screen in C. elegans reveals Parkinson’s drug candidates

24 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a workflow to study the behaviour of C. elegans in a high-throughput screen to identify Parkinson's disease drugs.

news

Over 87,000 papers published on coronavirus since start of pandemic

24 February 2021 | By Victoria Rees (Drug Target Review)

Between January and October 2020, scientists globally have published more than 87,000 papers about the coronavirus.

news

Team modifies therapeutic molecule to improve stroke treatment

19 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that adding a polymer to glutamate-oxaloacetate transaminase means the molecule can treat stroke for up to six days in rats.

news

New drug combination could combat Diffuse Intrinsic Pontine Glioma

17 February 2021 | By Victoria Rees (Drug Target Review)

The drug combination of difluoromethylornithine and AMXT 1501 has shown success against Diffuse Intrinsic Pontine Glioma in animal models.

article

Advancing neutralising antibody therapies for COVID-19

17 February 2021 | By Hannah Balfour (Drug Target Review)

In this article, Ian Chan, Chief Executive Officer and Co-Founder of biotech company Abpro, discusses the development of neutralising antibodies for SARS-CoV-2. Abpro’s neutralising antibody candidate ABP 300 is currently in Phase II/III trials.

article

SARS-CoV-2 and immunology: antibody developments

15 February 2021 | By Victoria Rees (Drug Target Review)

Discover the latest in SARS-CoV-2 antibody research as we cover three of the most recent developments in this article.

news

CNS target could lead to development of drugs for diabetes

11 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that a GLP-1/GIP dual-agonist targets the GIP receptor in the brain and CNS to reduce body weight and food intake.

news

Scientists reveal four discoveries about early SARS-CoV-2 infection

11 February 2021 | By Victoria Rees (Drug Target Review)

Researchers studying SARS-CoV-2 at the individual cellular level have made four major discoveries about early infection from the coronavirus.

news

ProAgio drug shows success against solid tumours in mice

10 February 2021 | By Victoria Rees (Drug Target Review)

Studies in mice have shown that the drug ProAgio is effective at treating pancreatic cancer and triple-negative breast cancer.

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Drug Development