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Raman imaging technique shows Alzheimer’s disease progress in the brain

24 January 2018 | By Drug Target Review

Using Raman optical technology, scientists can now produce images of brain tissue that is affected by Alzheimer’s disease...

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Altered gut microbiome populations may cause blood infections in paediatric cancer patients

24 January 2018 | By Drug Target Review

Scientists discover that altered gut microbiome populations appear to influence the onset of blood infections in paediatric cancer patients.

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Pixelated gene expression tool provides fast accurate results for RNA analysis

22 January 2018 | By Drug Target Review

Researchers have demonstrated how a pixelated gene expression tool can accurately measure RNA levels more quickly than existing methods allow.

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HIV-1 genetic diversity is higher in vaginal tract than in blood during early infection

19 January 2018 | By Dr Zara Kassam (Drug Target Review)

New evidence supports the existence of genetic 'sieve' on the path from vaginal tract to bloodstream...

news

Industry-academic collaboration results in improved understanding of cancer cell regulation

12 January 2018 | By Drug Target Review

A team of researchers from the University of Liverpool and AstraZeneca has made an important contribution to our understanding of cancer cell regulation, holding promise for improved future cancer treatment.

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Drugs targeting the cells circadian rhythm offers hope for glioblastoma

11 January 2018 | By Dr Zara Kassam (Drug Target Review)

An experimental drug demonstrated selective cancer-killing ability against breast, colon, leukaemia, brain and melanoma cancer cells with no apparent effects on normal cells...

news

Scientists identify potential therapeutic target for HER2-driven breast cancer

11 January 2018 | By Drug Target Review

Researchers have made a unique discovery about the role of the MED1 protein in breast cancer formation, showing it to be a promising therapeutic target worthy of future study.

news

Functioning human muscle grown from induced pluripotent stem cells

9 January 2018 | By Dr Zara Kassam (Drug Target Review)

First functioning human muscle grown from induced pluripotent stem cells holds promise for cellular therapies, drug discovery and studying rare diseases...

news

Promising preclinical drug candidate suppresses HIV

9 January 2018 | By Dr Zara Kassam (Drug Target Review)

A team of researchers have tested a chemical compound that suppresses HIV, protects immune cells, and remains effective for weeks with a single dose...

news

X chromosome reactivation could treat Rett syndrome

8 January 2018 | By Dr Zara Kassam (Drug Target Review)

Reactivation of the inactive X chromosome could lead to an increased expression of the healthy protein underlying the neurodevelopmental disorder...

news

Thorase protein may be linked to schizophrenia

4 January 2018 | By Dr Zara Kassam (Drug Target Review)

Epilepsy drug reverses anti-social behaviours in mice with genes that produce variant proteins...

news

A2aAR protein holds clues for better drug design

2 January 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have investigated a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases...

Groundbreaking gene therapy trial set to cure haemophilia

news

Groundbreaking gene therapy trial set to cure haemophilia

14 December 2017 | By Drug Target Review

A cure for haemophilia is one step closer, following results of a gene therapy trial led by the NHS in London.

Identification of hits and leads for human African trypanosomiasis

article

Identification of hits and leads for human African trypanosomiasis

13 December 2017 | By Dr Sheraz Gul, Giulia Pasini, Maria Paola Costi

Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...

Patient-derived neural progenitor cells as a drug discovery model for mitochondrial diseases

article

Patient-derived neural progenitor cells as a drug discovery model for mitochondrial diseases

13 December 2017 | By Alessandro Prigione, Carmen Lorenz, Gizem Inak

Mitochondrial DNA (mtDNA) mutations cause severe disorders that are untreatable and mostly affect the nervous system. The difficulty in funding therapies may also be explained by the lack of viable modelling systems...

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