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Raman imaging technique shows Alzheimer’s disease progress in the brain
Using Raman optical technology, scientists can now produce images of brain tissue that is affected by Alzheimer’s disease...
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Disease research
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Altered gut microbiome populations may cause blood infections in paediatric cancer patients
Scientists discover that altered gut microbiome populations appear to influence the onset of blood infections in paediatric cancer patients.
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Pixelated gene expression tool provides fast accurate results for RNA analysis
Researchers have demonstrated how a pixelated gene expression tool can accurately measure RNA levels more quickly than existing methods allow.
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HIV-1 genetic diversity is higher in vaginal tract than in blood during early infection
New evidence supports the existence of genetic 'sieve' on the path from vaginal tract to bloodstream...
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Industry-academic collaboration results in improved understanding of cancer cell regulation
A team of researchers from the University of Liverpool and AstraZeneca has made an important contribution to our understanding of cancer cell regulation, holding promise for improved future cancer treatment.
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Drugs targeting the cells circadian rhythm offers hope for glioblastoma
An experimental drug demonstrated selective cancer-killing ability against breast, colon, leukaemia, brain and melanoma cancer cells with no apparent effects on normal cells...
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Scientists identify potential therapeutic target for HER2-driven breast cancer
Researchers have made a unique discovery about the role of the MED1 protein in breast cancer formation, showing it to be a promising therapeutic target worthy of future study.
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Functioning human muscle grown from induced pluripotent stem cells
First functioning human muscle grown from induced pluripotent stem cells holds promise for cellular therapies, drug discovery and studying rare diseases...
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Promising preclinical drug candidate suppresses HIV
A team of researchers have tested a chemical compound that suppresses HIV, protects immune cells, and remains effective for weeks with a single dose...
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X chromosome reactivation could treat Rett syndrome
Reactivation of the inactive X chromosome could lead to an increased expression of the healthy protein underlying the neurodevelopmental disorder...
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Thorase protein may be linked to schizophrenia
Epilepsy drug reverses anti-social behaviours in mice with genes that produce variant proteins...
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A2aAR protein holds clues for better drug design
Scientists have investigated a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases...
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Groundbreaking gene therapy trial set to cure haemophilia
A cure for haemophilia is one step closer, following results of a gene therapy trial led by the NHS in London.
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Identification of hits and leads for human African trypanosomiasis
Neglected tropical diseases (NTD) affect more than one billion people and new targets and drugs are needed to tackle these infections. The multi-disciplinary NMTrypI consortium has identified a number of different compound classes which could be effective against these diseases. This article reviews some of these compounds...
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Patient-derived neural progenitor cells as a drug discovery model for mitochondrial diseases
Mitochondrial DNA (mtDNA) mutations cause severe disorders that are untreatable and mostly affect the nervous system. The difficulty in funding therapies may also be explained by the lack of viable modelling systems...
