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Disease research

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‘CRISPR babies’ may have shorter life expectancy

6 June 2019 | By Drug Target Review

A study of almost half a million people links a mutation that protects against HIV infection to an earlier death.

news

Update on the development of new novel cancer immunotherapy

24 May 2019 | By Drug Target Review

The SCIB2 vaccine is to to be administered using new nanoparticle formulation in planned Phase 1/2 clinical trial.

news

New study finally explains the link between inflammation and gastric cancer

17 April 2019 | By Drug Target Review

Researchers have finally shown how inflammation caused by H. pylori infection causes the proliferation of gastric epithelial stem cells, leading to gastric tumours.

news

Artificial chemical receptor developed to assist in T cell engineering

15 April 2019 | By Drug Target Review

Engineered T cell immunotherapy (such as chimeric antigen receptor T cell (CAR-T) and T cell receptor T cell (TCR-T) therapy), could potentially be used as a therapeutic strategy for tumour treatment.

news

Single-cell sequencing reveals landscape of immune cell subtypes in lung cancer tumours

10 April 2019 | By Drug Target Review

Researchers have used single-cell sequencing to map the landscape of myeloid cells in tumours from patients with lung cancer...

news

New DNA ‘shredder’ technique goes beyond CRISPR’s scissors

9 April 2019 | By Drug Target Review

A new CRISPR-based tool that acts more like a shredder is able to wipe out long stretches of DNA in human cells with programmable targeting...

news

Zebrafish reveal insights into Parkinson’s

9 April 2019 | By Drug Target Review

The findings offer clues that could one day lead to treatments for the neurological condition...

news

Cancer vaccine shows promising results in Lynch syndrome

8 April 2019 | By Fraser Owen (Drug Target Review)

Vaccination with as few as four tumour antigens generated antigen-specific responses, reduced intestinal tumours, and improved survival in a mouse model of Lynch syndrome...

news

Scientists decipher 3D structure of promising molecular target for cancer treatment

5 April 2019 | By Drug Target Review

Columbia University discovery could be a major step in developing therapies for cancer, controlling cholesterol...

news

Gut microbiome directs immune system to fight cancer

4 April 2019 | By Drug Target Review

The advent of immune checkpoint inhibitors is a major breakthrough in cancer immunotherapy...

news

Paving the path towards precision medicine

21 March 2019 | By Drug Target Review

A method to view the immune cell 'landscape' of bowel cancer tumours could pave the way towards more individualised medicine and treatment...

news

Epigenetic protein could be new therapeutic target in acute myeloid leukemia

19 March 2019 | By Drug Target Review

The epigenetic protein, EZH2, was found to delay the development of acute myeloid leukemia (AML) but also switches sides to maintain tumour growth...

news

Ticagrelor reversal agent provides immediate and sustained relief

18 March 2019 | By Drug Target Review

A reversal agent that sustains immediate relief from the side effects of ticagrelor stopping major bleeding, such as gastrointestinal hemorrhage...

news

Optical imaging technique to detect tiny tumours

8 March 2019 | By Iqra Farooq (Drug Target Review)

A method of imaging using longer wavelengths could mean that tiny tumours and clusters of cancer cells may be detected earlier than current methods allow...

news

Potential EBV-associated cancer treatment in small molecule inhibitors

7 March 2019 | By Iqra Farooq (Drug Target Review)

A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...

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