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Disease research

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New tool reveals DNA structures that influence disease

19 December 2019 | By Fraser Owen (Drug Target Review)

Researchers have created an algorithm that locates and analyses DNA structures which are linked to the development of certain diseases.

article

DTR’s news round-up 2019: the stories that defined the year

18 December 2019 | By Drug Target Review

Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.

news

Origins and potential therapies for a neurodegenerative disorder found

18 December 2019 | By Rachael Harper (Drug Target Review)

Various potential therapeutic opportunities to treat spinocerebellar ataxia type 7 (SCA7) have been discovered in a new study into the neurodegenerative disorder.

news

Novel mouse model to study melanoma developed

18 December 2019 | By Victoria Rees (Drug Target Review)

Researchers have created a novel genetically engineered mouse model for the study of melanoma that they say is more efficient than traditional models.

news

Multi-omics approach yields novel insight for peanut allergies

17 December 2019 | By Drug Target Review

Researchers in New York have identified novel genes associated with the severity of peanut allergies and noted how these genes interact with other genes during allergic reactions. The findings could lead to better treatments for peanut allergies.

news

New insights found into lupus may help combat the disease

17 December 2019 | By Rachael Harper (Drug Target Review)

A new study may lead to new treatments for lupus as it has found that, when impaired, a key regulator of the immune system can cause damaging immune system attacks on skin and organs, which are hallmarks of the disease.

article

A novel approach to unravelling the mysteries of Alzheimer’s

16 December 2019 | By Dr Sean Devenish (Fluidic Analytics), Professor Tuomas Knowles (University of Cambridge)

The heterogenous and dynamic nature of protein aggregates makes them a particularly challenging class of structures to study. In this article, Professor Tuomas Knowles and Dr Sean Devenish present a novel approach to studying protein structures that could aid in understanding the complexities of Alzheimer’s disease and identify future therapeutic…

article

Hit-to-lead in neglected diseases – it’s a numbers game

16 December 2019 | By Nikki Withers (Drug Target Review)

The hit-to-lead journey can be a long endeavour, with many failures along the way. Nikki Withers spoke with DNDi ’s Discovery Director Dr Charles Mowbray to hear how the organisation is working to identify new leads with activity in animal models of neglected tropical diseases and the potential for further…

news

Extensive tumour protein analysis reveals new therapy targets

16 December 2019 | By Hannah Balfour (Drug Target Review)

New research has categorised hundreds of cancers based on their common protein mutations, highlighting cell components and tumour microenvironments as possible new therapy targets.

news

Previously unknown role of dendritic cells in inflammation revealed

13 December 2019 | By Victoria Rees (Drug Target Review)

A study has demonstrated that dendritic cells play a key role in inflammation and how TNF inhibitors can prevent them from fighting infections.

article

CRISPR: kick-starting the revolution in drug discovery

13 December 2019 | By Dr Pushpanathan Muthuirulan (Harvard University)

Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…

article

Open innovation – a collaboration between academia and the pharmaceutical industry to further leverage drug discovery expertise and assets

13 December 2019 | By Dr David Murray (AstraZeneca), Dr Mark Wigglesworth (AstraZeneca), Marian Preston (AstraZeneca)

Increasing numbers of companies in the pharma industry are consolidating their services and outsourcing to CROs to reduce business costs. AstraZeneca’s Marian Preston, David Murray and Mark Wigglesworth discuss how this can not only drive innovation but also prove successful in identifying lead compounds, as evidenced through recent collaborations.

news

New insights into major disease pathways made with protein discovery

13 December 2019 | By Rachael Harper (Drug Target Review)

A new chemical tool has been used to identify hundreds of modified proteins which allows new insights to major diseases.

news

Researchers find 150 possible inhibitors to fight Nipah virus

13 December 2019 | By Victoria Rees (Drug Target Review)

A group of scientists from India have used 3D imaging of the Nipah virus to discover potential inhibitors for the disease.

news

Promising new therapy developed to treat leukaemia

12 December 2019 | By Hannah Balfour (Drug Target Review)

VTP50469, a new targeted therapy for MLL-rearranged leukaemia, shows greater efficacy and fewer side-effects in mice, according to new research.

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