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New tool reveals DNA structures that influence disease
Researchers have created an algorithm that locates and analyses DNA structures which are linked to the development of certain diseases.
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Disease research
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DTR’s news round-up 2019: the stories that defined the year
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.
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Origins and potential therapies for a neurodegenerative disorder found
Various potential therapeutic opportunities to treat spinocerebellar ataxia type 7 (SCA7) have been discovered in a new study into the neurodegenerative disorder.
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Novel mouse model to study melanoma developed
Researchers have created a novel genetically engineered mouse model for the study of melanoma that they say is more efficient than traditional models.
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Multi-omics approach yields novel insight for peanut allergies
Researchers in New York have identified novel genes associated with the severity of peanut allergies and noted how these genes interact with other genes during allergic reactions. The findings could lead to better treatments for peanut allergies.
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New insights found into lupus may help combat the disease
A new study may lead to new treatments for lupus as it has found that, when impaired, a key regulator of the immune system can cause damaging immune system attacks on skin and organs, which are hallmarks of the disease.
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A novel approach to unravelling the mysteries of Alzheimer’s
The heterogenous and dynamic nature of protein aggregates makes them a particularly challenging class of structures to study. In this article, Professor Tuomas Knowles and Dr Sean Devenish present a novel approach to studying protein structures that could aid in understanding the complexities of Alzheimer’s disease and identify future therapeutic…
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Hit-to-lead in neglected diseases – it’s a numbers game
The hit-to-lead journey can be a long endeavour, with many failures along the way. Nikki Withers spoke with DNDi ’s Discovery Director Dr Charles Mowbray to hear how the organisation is working to identify new leads with activity in animal models of neglected tropical diseases and the potential for further…
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Extensive tumour protein analysis reveals new therapy targets
New research has categorised hundreds of cancers based on their common protein mutations, highlighting cell components and tumour microenvironments as possible new therapy targets.
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Previously unknown role of dendritic cells in inflammation revealed
A study has demonstrated that dendritic cells play a key role in inflammation and how TNF inhibitors can prevent them from fighting infections.
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CRISPR: kick-starting the revolution in drug discovery
Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…
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Open innovation – a collaboration between academia and the pharmaceutical industry to further leverage drug discovery expertise and assets
Increasing numbers of companies in the pharma industry are consolidating their services and outsourcing to CROs to reduce business costs. AstraZeneca’s Marian Preston, David Murray and Mark Wigglesworth discuss how this can not only drive innovation but also prove successful in identifying lead compounds, as evidenced through recent collaborations.
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New insights into major disease pathways made with protein discovery
A new chemical tool has been used to identify hundreds of modified proteins which allows new insights to major diseases.
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Researchers find 150 possible inhibitors to fight Nipah virus
A group of scientists from India have used 3D imaging of the Nipah virus to discover potential inhibitors for the disease.
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Promising new therapy developed to treat leukaemia
VTP50469, a new targeted therapy for MLL-rearranged leukaemia, shows greater efficacy and fewer side-effects in mice, according to new research.
