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Coronavirus update: recent developments in vaccine research

27 February 2020 | By Hannah Balfour (Drug Target Review)

Drug Target Review’s round-up of the latest developments in 2019 novel coronavirus (COVID-19 or SARS-CoV-2) therapeutics and vaccines.

Y-shaped antibody interacting with cell surface

article

Why invest in creating a modifiable drug framework?

27 February 2020 | By Hannah Balfour (Drug Target Review)

Drug Target Review spoke with CUE Biopharma’s President and CSO to find out how and why they created the ImmunoSTAT platform and the ways it may benefit drug design in the future.

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Natural killer cells identified as source of inflammation in rheumatoid arthritis

26 February 2020 | By Victoria Rees (Drug Target Review)

A study has shown that natural killer cells are linked to the protein GM-CSF, which causes inflammation, indicating a new target for rheumatoid arthritis.

Artist impression of a nucleus, cut open to reveal DNA with chromatin core inside

news

Non-coding RNA may interact with chromatin to control gene expression

26 February 2020 | By Hannah Balfour (Drug Target Review)

The development of an innovative new technology has led researchers to suggest RNA-chromatin interactions may play a role in gene regulation.

MRI scan of a traumatic brain injury with affected area highlighted in red

news

Depletion and repopulation of microglia could be a future therapy for TBI

26 February 2020 | By Hannah Balfour (Drug Target Review)

Researchers have shown that by effectively resetting the microglia, recovery of mice after a traumatic brain injury (TBI) was improved.

news

RCAN1 gene revealed as regulator of Down syndrome symptom

25 February 2020 | By Victoria Rees (Drug Target Review)

A study has shown that the RCAN1 gene plays a role in regulating synaptic plasticity, which contributes to a sympom of Down syndrome.

artist drawing of anatomy with pancreas highlighted

news

ILC2s sensitise pancreatic tumours to PD-1 checkpoint inhibitors in mice

25 February 2020 | By Hannah Balfour (Drug Target Review)

Scientists identify innate lymphoid cells (ILCs) as possible targets for immunotherapies as their activation makes murine pancreatic tumours sensitive to PD-1 checkpoint inhibitors.

skeletal muscle section under the microscope

news

Utrophin as a novel therapeutic approach for Duchenne muscular dystrophy

25 February 2020 | By Hannah Balfour (Drug Target Review)

Upregulating utrophin using small molecules could be a new therapeutic approach for Duchenne muscular dystrophy (DMD).

article

Could dolphins be viable models for human brain disorders?

25 February 2020 | By Professor Giovanni Di Guardo (University of Teramo)

Neuropathologic similarities between dolphins and humans suggest that the former could act as an effective model for the study of diseases such as Alzheimer’s. Professor Giovanni Di Guardo explains why dolphins could provide researchers with a new window into neurodegenerative conditons.

news

New laser system developed for stainless imaging of vesicles

24 February 2020 | By Victoria Rees (Drug Target Review)

Using ultrashort laser pulses to interact with vesicles, researchers have created a novel label-free imaging method.

opticians image of the retina with a large area of macular degeneration

news

Toll-like receptor could be targeted to treat age-related macular degeneration

24 February 2020 | By Hannah Balfour (Drug Target Review)

Scientists have implicated toll-like receptor 2 (TLR2) in age-related macular degeneration and shown that knocking it out can improve symptoms in animal models.

news

L-serine could be used to treat ALS, after promising results in primate study

24 February 2020 | By Hannah Balfour (Drug Target Review)

Researchers have shown that, when treated with L-serine, a non-human primate model of ALS had fewer pathologies associated with the disease.

New worm model could aid in the study of rare disease1

news

New worm model could aid in the study of rare disease

21 February 2020 | By Rachael Harper (Drug Target Review)

A new earthworm model has been developed for the rare disease, x-ALD, which the scientists say could lead to pharmacological targets for the neuronal alterations of the disease.

news

Ptychographic label-free microscopy platform developed for imaging

21 February 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed a new label-free ptychographic microscopy method by bringing samples closer to the image sensor, reducing processing time.

news

Researchers gain new insight into LRRK2 – a potential cause of Parkinson’s

20 February 2020 | By Mandy Parrett (Drug Target Review)

Scientists in the US have applied a novel technique to finally unravel a particular kinase enzyme that is associated with familial Parkinson’s disease; providing a clearer potential therapeutic target.

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