whitepaper Application note: Effect of alkylamine based Ion-pairing reagents in analysis of siRNA 7 August 2020 | By Phenomenex Silencing RNA, or siRNA, are short, double-stranded RNA molecules which are not only an important research tool in molecular biology, but also an emerging therapeutic modality.
whitepaper Application note: Comparison of fully porous and superficially porous particles for the analysis of synthetic oligonucleotides 7 August 2020 | By Phenomenex Superficially porous particle technologies provide a reduced diffusion path in comparison with their fully porous counterparts minimising the resistance to mass transfer during chromatographic separation.
news Near-identical protein on SARS and COVID-19 could be targeted by FDA-approved drugs 3 August 2020 | By Victoria Rees (Drug Target Review) According to researchers, drugs that target envelope protein E on the SARS viral membrane could also be used to target a similar protein on COVID-19.
news New set of channels between malaria parasite and blood cells discovered 3 August 2020 | By Victoria Rees (Drug Target Review) A team has discovered channels that enable the transport of lipids between the malaria parasite and red blood cells during infection.
news Over 200 genes implicated in glioblastoma tumour growth 30 July 2020 | By Victoria Rees (Drug Target Review) A study has identified more than 200 genes that drive the progression of glioblastoma and which the researchers say present drug targets.
article Five developments in oncology targets 30 July 2020 | By Hannah Balfour (Drug Target Review) Drug Target Review explores some of the newest oncologic drug targets, including those for glioblastoma, lung cancer and breast cancer.
news Team suggest bradykinin system could be targeted by COVID-19 drugs 29 July 2020 | By Victoria Rees (Drug Target Review) Researchers say computational analyses suggest the bradykinin system may explain some of the symptoms of COVID-19, providing a drug target.
news LY6E identified as potential immunoprotein against SARS-CoV-2 29 July 2020 | By Victoria Rees (Drug Target Review) A study has demonstrated that the LY6E protein inhibits SARS-CoV-2 infection in human cell cultures, so a drug mimicking it could be a therapy for COVID-19.
news Study reveals microRNA as promising hair regrowth drug target 28 July 2020 | By Victoria Rees (Drug Target Review) Researchers have revealed that the microRNA miR-218-5p promoted hair growth in mice, so is a promising drug target for hair loss.
article A circuit involved in itching: from skin to sensory neurons 27 July 2020 | By Dr Santosh Mishra (North Carolina State Veterinary Medicine), Srisruti Bontala (North Carolina State Veterinary Medicine) Dr Santosh Mishra and Srisruti Bontala explain how they discovered a new cutaneous-nerve pathway for allergic itch in atopic dermatitis.
news Synapse protecting protein could be a target for Alzheimer’s therapies 22 July 2020 | By Hannah Balfour (Drug Target Review) Researchers suggest the SRPX2 protein, which inhibits complement system-dependent synapse removal could be a target for novel Alzheimer’s and schizophrenia therapies.
news Toxoplasma gondii hijacks host stress mechanisms to spread through the body 22 July 2020 | By Hannah Balfour (Drug Target Review) A new study reveals that the Toxoplasma gondii parasite acts through the IRE1 protein to cause infected cells to migrate through the body, spreading the parasite.
news Vitronectin could be a promising drug target for macular degeneration 21 July 2020 | By Hannah Balfour (Drug Target Review) Scientists demonstrate that vitronectin is responsible of the formation of deposits in dry age-related macular degeneration and suggest inhibitors could slow disease progression.
article Revealing the genetic signature of neurodegenerative disease 21 July 2020 | By Hannah Balfour (Drug Target Review) Which immune cells contribute towards immune-induced neurodegeneration and how could this knowledge enable conditions such Alzheimer’s and multiple sclerosis to be treated?
news Huntingtin protein disrupts axonal transport system within neurons 20 July 2020 | By Hannah Balfour (Drug Target Review) Researchers show that the mutated huntingtin protein associated with Huntington’s disrupts the transport of essential proteins within the neuron, potentially highlighting an early cause of the disease.
