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Disease research

glowing yellow pancreas and red and blue blood wessels in the anatomy of a human

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Researchers halt type 1 diabetes onset by denervating the pancreas

27 August 2020 | By Hannah Balfour (Drug Target Review)

Scientists denervated the pancreas using surgery or pharmacological agents to protect it from immune-mediated beta cell destruction, preventing the onset of type 1 diabetes.

news

Inhibiting growth factor signalling prevents SARS-CoV-2 replication, report researchers

26 August 2020 | By Hannah Balfour (Drug Target Review)

Scientists have patented their technique of inhibiting cellular growth factor signalling to stop SARS-CoV-2 replication and treat COVID-19.

SARS-CoV-2 coronavirus particle and an RNA strand both in red

news

Tracking SARS-CoV-2 evolution: notable mutations and potential targets

26 August 2020 | By Hannah Balfour (Drug Target Review)

Researchers report that while the spike protein and RNA polymerase proteins have stabilised, other regions of the SARS-CoV-2 genome are becoming increasingly variable.

news

Researchers suggest IgA antibodies are better at neutralising SARS-CoV-2

25 August 2020 | By Hannah Balfour (Drug Target Review)

Scientists have developed a novel secretory immunoglobulin A (sIgA) serotype antibody that binds more effectively to the spike protein of SARS-CoV-2 than some IgG antibodies.

news

Two biomarkers of COVID-19 disease survival identified by researchers

25 August 2020 | By Victoria Rees (Drug Target Review)

Scientists have revealed that the cytokines IL-6 and TNF-α are two biomarkers of inflammation that can predict the severity of COVID-19.

Parkinson's Disease dopamine neuron with alpha-synuclein Lewy Body inside

news

Novel alpha-synuclein structures could be the target for future Parkinson’s therapies

24 August 2020 | By Hannah Balfour (Drug Target Review)

Researchers observed new structures of alpha-synuclein aggregates in their study exploring how the presence of cell membrane phospholipids impacts protein aggregation.

cartoon pancreas with red 'tumour' highlighted

news

Inhibiting sortilin could make pancreatic cancer therapies more effective

21 August 2020 | By Hannah Balfour (Drug Target Review)

A study has shown that inhibiting sortilin, a neuroprotein known to have increased expression in cancers, reduces pancreatic cancer invasiveness in vitro.

whitepaper

ebook: A clear and easy guide to Luminex^® multiplex immunoassays

19 August 2020 | By Bio-Techne

Multiplexing allows multiple biological target analytes to be simultaneously examined and quantified in a single sample. It’s a technique widely used by scientific researchers of all disciplines and provides many benefits.

news

Researchers identify protein that may help SARS-CoV-2 spread through cells

14 August 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the SARS-CoV-2 nucleocapsid protein may help the virus to spread from cell to cell, providing a drug target.

news

Five biomarkers revealed as indicators of COVID-19 patient survival

10 August 2020 | By Victoria Rees (Drug Target Review)

Five immune response biomarkers have been identified by researchers who say they can be used to classify which COVID-19 patients will survive the disease.

news

Raman technique developed for high-throughput discovery of enzymes

10 August 2020 | By Victoria Rees (Drug Target Review)

A flow mode Raman-activated cell sorter called FlowRACS has been created by researchers for high-throughput discovery of enzymes and their cell factories.

news

Algorithm to predict sites of DNA methylation and drug targets developed

7 August 2020 | By Victoria Rees (Drug Target Review)

A machine learning algorithm that predicts sites of DNA methylation could aid in the identification of disease-causing mechanisms, say researchers.

whitepaper

Application note: The effect of column hardware on the analysis of synthetic oligonucleotides by LC-MS

7 August 2020 | By Phenomenex

Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry.

whitepaper

Application note: Effect of temperature on single stranded oligonucleotide analysis

7 August 2020 | By Phenomenex

Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry. However, characterisation of oligos, specifically by ion-pair reversed phase liquid chromatography (IPRPLC), can be quite challenging.

whitepaper

Application note: Effect of perfluorinated alcohols in impurity analysis for synthetic oligonucleotides

7 August 2020 | By Phenomenex

Therapeutic oligonucleotides represent a recent breakthrough in the pharmaceutical industry.

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Disease research